Results for Health
130,725 grants found
Showing 126,701 – 126,720 of 130,725 grants for "Health"
Reducing Ethnic-racial Disparities in Cardiac Arrest Survival Outcomes (RED-CASO)
PROJECT SUMMARY / ABSTRACT The public health burden of out-of-hospital cardiac arrest (OHCA) is enormous, affecting ~350,000 individuals each year in the U.S. and is the third lead...
High-Throughput, Rapid, and Epitope-Specific Quantification of Neutralizing Antibodies Using Digital Nanoparticle Sensors
Project Summary/Abstract As of mid June 2021, the new coronavirus disease (COVID-19), caused by SARS-CoV-2 virus, has infected ~180 million people and causing ~3.8 million deaths g...
Designing with dissemination in mind: Development and evaluation of a theory-based physical activity intervention using the Multiphase Optimization Strategy
PROJECT SUMMARY/ABSTRACT Difficulty adhering to prescribed health behaviors significantly hinders the long-term benefits of lifestyle weight management programs, leading to an incr...
Prioritizing autoimmune-associated genetic variants that alter regulatory element activity in B cells
SUMMARY Genome-wide association studies have discovered hundreds of genetic loci throughout the genome that associate with autoimmune diseases. However, the causal genetic variants...
Conference: Society for Research on Biological Rhythms: From Molecules to Policy
Nearly all organisms have evolved molecular, cellular, physiological and behavioral adaptations to predict regular oscillations in the environment. As such, biological rhythms are...
Direct Transduction and Regulation of Pathological Pain by Neuronal TRPM2 Channels
Pathological pain remains a major unmet clinical problem accounting for up to 80% of physician visits. Chronic arthritis pain is particularly debilitating and can last for a lifeti...
Designing with dissemination in mind: Development and evaluation of a theory-based physical activity intervention using the Multiphase Optimization Strategy
PROJECT SUMMARY/ABSTRACT Difficulty adhering to prescribed health behaviors significantly hinders the long-term benefits of lifestyle weight management programs, leading to an incr...
Classical and Alternative Renin-Angiotensin System Dysregulation in Sepsis-Associated AKI: A Reverse Translation Approach
PROJECT SUMMARY/ABSTRACT This proposal includes a five-year research career development program to study classical and alternative renin-angiotensin system (RAS) dysregulation in s...
Myeloid-specific IRE1alpha as a mediator of nonalcoholic fatty liver disease
PROJECT SUMMARY/ABSTRACT Alongside the unabating global obesity crisis, there has been a rise in non-alcoholic fatty liver disease (NAFLD), now affecting as many as ~1-in-3 America...
Classical and Alternative Renin-Angiotensin System Dysregulation in Sepsis-Associated AKI: A Reverse Translation Approach
PROJECT SUMMARY/ABSTRACT This proposal includes a five-year research career development program to study classical and alternative renin-angiotensin system (RAS) dysregulation in s...
Elucidating the role of the microbiome in inducing gut permeability and inflammation
Project Summary/Abstract Background – The microbiome affects host metabolism predominantly via metabolites synthesized or modified by gut bacteria. The identity of these metabolite...
Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
A central problem in ovarian cancer is late diagnosis, which causes the 5-year survival rate to plummet below 50%. Ovarian cancer symptoms are vague and nonspecific, and current sc...
Unraveling the role of endothelium in chemotherapy-induced cardiotoxicity
Project Summary/Abstract Doxorubicin is a highly effective chemotherapy drug commonly used to treat multiple cancers, but its use is limited due to cardiotoxicity. Cardiotoxicity c...
Effects of semaglutide on bone and muscle endpoints in adults with obesity: a pilot study.
PROJECT SUMMARY/ABSTRACT Obesity is a growing epidemic, with more than two-thirds of adults in the United States overweight or obese. Although diet-induced weight loss reduces obes...
Seizures and Children's Outcomes after Stroke (SCOUTS)
PROJECT SUMMARY/ABSTRACT Epilepsy is one of the common problems that can result after ischemic stroke in a child. Children with post- stroke epilepsy have poorer cognitive outcomes...
Uncovering the Mechanism of Potassium Channel Folding and Assembly with Implications for the Molecular Basis of Cardiac Arrhythmia
Project Summary/Abstract Potassium channels are membrane proteins critical for the electrochemical regulation and function of cardiac cells. Many diseases are associated with mutat...
Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain
Degeneration or breakdown of the myelin sheath that wraps and insulates axons of the central nervous system, as well as peripheral nerves, is a factor in a large array of neurologi...
Lung epithelial cell reprogramming by CD4 T cells
PROJECT SUMMARY Candidate Information: I am a postdoctoral fellow in Dr. Joseph Mizgerd’s lab at Boston University Pulmonary Center since Jan-2018 and my work has focused on elucid...
Antigenic variation of Mycoplasma genitalium during persistent genital tract infection of pig-tailed macaques
PROJECT SUMMARY Mycoplasma genitalium (MG), a sexually transmitted bacterial pathogen, is increasingly recognized as a significant public health concern. The prevalence of MG range...
Anatomic microniches and their contribution to vascular remodeling in pulmonary hypertension
Pulmonary hypertension (PH) is a poorly understood disease that causes pathologic remodeling of the smaller diameter vessels of the lung, leading to progressive heart failure. This...