Results for Health
130,725 grants found
Showing 126,781 – 126,800 of 130,725 grants for "Health"
Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV
Opioid driven exacerbations of neuropathological events and alterations in HIV transcription contributing to HIV associated CNS dysfunction are well-reported. Despite years of cont...
Investigating a novel role for Top2a in R-loop resolution and in YM155 mechanism of action
R-loops are DNA:RNA hybrids formed when newly transcribed RNA binds to its complementary DNA template, preventing reannealing of the two DNA strands. R-loops occur naturally and pl...
Age-related changes in skeletal muscle and lower urinary tract symptoms in older adults
PROJECT SUMMARY/ABSTRACT There is a fundamental knowledge gap and missed opportunities due to the current lack of understanding of the relationship between age-related risk factors...
Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV
Opioid driven exacerbations of neuropathological events and alterations in HIV transcription contributing to HIV associated CNS dysfunction are well-reported. Despite years of cont...
RCT to evaluate Bystander-informed See it Stop it (BiSiSi) to Prevent Child Sex Trafficking in Kentucky Middle Schools
The strongest risk factor for child sexual exploitation and trafficking (CSE/T) is a dysfunctional family environment characterized by violence and parental substance use. In Kentu...
Interactive Software for Assessing Meaningful Cognitive Function
PROJECT SUMMARY Alzheimer?s disease (AD) and AD-related dementias (ADRD) are associated with significant disability and loss of independence, burden, and costs to affected individu...
Feasibility and acceptability of an online program to promote physical activity among black women
ABSTRACT Research demonstrates the health-related benefits of participation in daily physical activity (PA), including prevention and treatment of chronic diseases.Despite this kno...
The Role of Permit-to-Purchase in the Primary Prevention of Multiple Forms of Violence
Abstract: Permit-to-purchase (PTP) laws for handguns are state-level policies that creates a robust system to restrict access to guns by prohibited individuals and deter straw purc...
Identification of novel contributors to retinitis pigmentosa using metabolic and proteomic approaches
ABSTRACT Retinitis pigmentosa (RP) is a progressive form of retinal degeneration caused by at least 3,000 mutations in 70 different genes that result in the death of rods, followed...
Novel precision medicine approach to treatment of osteoporosis based on bone turnover
1. Project Summary/Abstract Osteoporosis is a health problem of major proportions. It affects more than 40 million Americans and results in more than 2 million fractures annually a...
RCT to evaluate Bystander-informed See it Stop it (BiSiSi) to Prevent Child Sex Trafficking in Kentucky Middle Schools
The strongest risk factor for child sexual exploitation and trafficking (CSE/T) is a dysfunctional family environment characterized by violence and parental substance use. In Kentu...
Novel precision medicine approach to treatment of osteoporosis based on bone turnover
1. Project Summary/Abstract Osteoporosis is a health problem of major proportions. It affects more than 40 million Americans and results in more than 2 million fractures annually a...
Identification of novel contributors to retinitis pigmentosa using metabolic and proteomic approaches
ABSTRACT Retinitis pigmentosa (RP) is a progressive form of retinal degeneration caused by at least 3,000 mutations in 70 different genes that result in the death of rods, followed...
The Role of Permit-to-Purchase in the Primary Prevention of Multiple Forms of Violence
Abstract: Permit-to-purchase (PTP) laws for handguns are state-level policies that creates a robust system to restrict access to guns by prohibited individuals and deter straw purc...
Evaluation of the school-based Healthy Relationships Project for primary prevention of child sexual abuse among children pre-K through 5th grade
Project Abstract Evaluation of the school-based Healthy Relationships Project for primary prevention of child sexual abuse among children pre-K through 5th grade Child sexual abuse...
Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV
Opioid driven exacerbations of neuropathological events and alterations in HIV transcription contributing to HIV associated CNS dysfunction are well-reported. Despite years of cont...
Feasibility and acceptability of an online program to promote physical activity among black women
ABSTRACT Research demonstrates the health-related benefits of participation in daily physical activity (PA), including prevention and treatment of chronic diseases. Despite this kn...
A behavioral intervention to optimize self-management of celiac disease in adolescents
PROJECT SUMMARY/ABSTRACT Celiac disease (CD) is a chronic autoimmune condition whose only currently available treatment is a strict, burdensome gluten-free diet (GFD). The current...
Development of Conformer-Specific Anti-HLA Class II mAbs
Summary: Murine MHC class II molecules exist in two distinct conformational states formed by differential pairing of class II transmembrane (TM) domain GxxxG dimerization motifs (i...
Gonococcal peptide vaccine candidate display using HPV virus-like particles
ABSTRACT About 87 million new cases of gonorrhea occur globally, annually. In 2018, 583,405 cases were reported in the U.S, an 82.6% increase in disease incidence since the histori...