Results for Health
130,725 grants found
Showing 126,801 – 126,820 of 130,725 grants for "Health"
Development of Conformer-Specific Anti-HLA Class II mAbs
Summary: Murine MHC class II molecules exist in two distinct conformational states formed by differential pairing of class II transmembrane (TM) domain GxxxG dimerization motifs (i...
Telemetric Regenerative Bandage for Accelerating Wound Healing
Summary Diabetic foot ulcers (DFUs) are a major complication of diabetes. These sores, if left untreated, can become infected and become a serious threat to the patient?s well bein...
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitis
Abstract Infectious osteomyelitis (OM) is an inflammation-driven disease of bone that culminates in pathological alterations in skeletal architecture. Bone infections are multifact...
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitis
Abstract Infectious osteomyelitis (OM) is an inflammation-driven disease of bone that culminates in pathological alterations in skeletal architecture. Bone infections are multifact...
Role of NLRP3 signals in ischemia/reperfusion-induced organ injury
Project Summary: This proposal evaluates how intracellular signaling pathways generated by the cytoplasmic innateimmune receptor NLRP3 are regulated in renal tubular epithelial cel...
Role of NLRP3 signals in ischemia/reperfusion-induced organ injury
Project Summary: This proposal evaluates how intracellular signaling pathways generated by the cytoplasmic innateimmune receptor NLRP3 are regulated in renal tubular epithelial cel...
Role of NLRP3 signals in ischemia/reperfusion-induced organ injury
Project Summary: This proposal evaluates how intracellular signaling pathways generated by the cytoplasmic innateimmune receptor NLRP3 are regulated in renal tubular epithelial cel...
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitis
Abstract Infectious osteomyelitis (OM) is an inflammation-driven disease of bone that culminates in pathological alterations in skeletal architecture. Bone infections are multifact...
Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV
Opioid driven exacerbations of neuropathological events and alterations in HIV transcription contributing to HIV associated CNS dysfunction are well-reported.Despite years of conti...
Investigating a novel role for Top2a in R-loop resolution and in YM155 mechanism of action
R-loops are DNA:RNA hybrids formed when newly transcribed RNA binds to its complementary DNA template, preventing reannealing of the two DNA strands.R-loops occur naturally and pla...
Novel precision medicine approach to treatment of osteoporosis based on bone turnover
1. Project Summary/Abstract Osteoporosis is a health problem of major proportions.It affects more than 40 million Americans and results in more than 2 million fractures annually am...
Identification of novel contributors to retinitis pigmentosa using metabolic and proteomic approaches
ABSTRACT Retinitis pigmentosa (RP) is a progressive form of retinal degeneration caused by at least 3,000 mutations in 70 different genes that result in the death of rods, followed...
Differentiated interventions to support HIV PrEP persistence in patients with substance use
ABSTRACT/PROJECT SUMMARY Dr.Hojilla's long-term career goal is to become an independently funded investigator with expertise in HIV prevention and precision behavioral interve...
Age-related changes in skeletal muscle and lower urinary tract symptoms in older adults
PROJECT SUMMARY/ABSTRACT There is a fundamental knowledge gap and missed opportunities due to the current lack of understanding of the relationship between age-related risk factors...
Telemetric Regenerative Bandage for Accelerating Wound Healing
Summary Diabetic foot ulcers (DFUs) are a major complication of diabetes. These sores, if left untreated, can become infected and become a serious threat to the patient’s well bein...
Association between cannabis and pain outcomes in a Tribally operated clinic
ABSTRACT American Indians and Alaska Native (AIAN) people are disproportionately affected by chronic pain conditions, including arthritis, diabetic neuropathy, and lower back pain....
Association between cannabis and pain outcomes in a Tribally operated clinic
ABSTRACT American Indians and Alaska Native (AIAN) people are disproportionately affected by chronic pain conditions, including arthritis, diabetic neuropathy, and lower back pain....
Telemetric Regenerative Bandage for Accelerating Wound Healing
Summary Diabetic foot ulcers (DFUs) are a major complication of diabetes. These sores, if left untreated, can become infected and become a serious threat to the patient’s well bein...
Role of NLRP3 signals in ischemia/reperfusion-induced organ injury
Project Summary: This proposal evaluates how intracellular signaling pathways generated by the cytoplasmic innate immune receptor NLRP3 are regulated in renal tubular epithelial ce...
Association between cannabis and pain outcomes in a Tribally operated clinic
ABSTRACT American Indians and Alaska Native (AIAN) people are disproportionately affected by chronic pain conditions, including arthritis, diabetic neuropathy, and lower back pain....