Results for Health
130,725 grants found
Showing 126,821 – 126,840 of 130,725 grants for "Health"
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitis
Abstract Infectious osteomyelitis (OM) is an inflammation-driven disease of bone that culminates in pathological alterations in skeletal architecture. Bone infections are multifact...
Telemetric Regenerative Bandage for Accelerating Wound Healing
Summary Diabetic foot ulcers (DFUs) are a major complication of diabetes. These sores, if left untreated, can become infected and become a serious threat to the patient’s well bein...
Role of NLRP3 signals in ischemia/reperfusion-induced organ injury
Project Summary: This proposal evaluates how intracellular signaling pathways generated by the cytoplasmic innateimmune receptor NLRP3 are regulated in renal tubular epithelial cel...
A behavioral intervention to optimize self-management of celiac disease in adolescents
PROJECT SUMMARY/ABSTRACT Celiac disease (CD) is a chronic autoimmune condition whose only currently available treatment is a strict, burdensome gluten-free diet (GFD). The current...
Determining the Injury-Associated Microbial Nutrients that Facilitate Secondary Bacterial Infection in Acutely Injured Lungs
PROJECT SUMMARY Secondary pneumonia occurs frequently in patients with acutely injured lungs and increases the mortality of acute lung injury. Although acute lung injury is caused...
Myeloid-specific IRE1alpha as a mediator of nonalcoholic fatty liver disease
PROJECT SUMMARY/ABSTRACT Alongside the unabating global obesity crisis, there has been a rise in non-alcoholic fatty liver disease (NAFLD), now affecting as many as ~1-in-3 America...
Uncovering the Mechanism of Potassium Channel Folding and Assembly with Implications for the Molecular Basis of Cardiac Arrhythmia
Project Summary/Abstract Potassium channels are membrane proteins critical for the electrochemical regulation and function of cardiac cells. Many diseases are associated with mutat...
Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
A central problem in ovarian cancer is late diagnosis, which causes the 5-year survival rate to plummet below 50%. Ovarian cancer symptoms are vague and nonspecific, and current sc...
Determining the Injury-Associated Microbial Nutrients that Facilitate Secondary Bacterial Infection in Acutely Injured Lungs
PROJECT SUMMARY Secondary pneumonia occurs frequently in patients with acutely injured lungs and increases the mortality of acute lung injury. Although acute lung injury is caused...
Classical and Alternative Renin-Angiotensin System Dysregulation in Sepsis-Associated AKI: A Reverse Translation Approach
PROJECT SUMMARY/ABSTRACT This proposal includes a five-year research career development program to study classical and alternative renin-angiotensin system (RAS) dysregulation in s...
Unraveling the role of endothelium in chemotherapy-induced cardiotoxicity
Project Summary/Abstract Doxorubicin is a highly effective chemotherapy drug commonly used to treat multiple cancers, but its use is limited due to cardiotoxicity. Cardiotoxicity c...
Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
A central problem in ovarian cancer is late diagnosis, which causes the 5-year survival rate to plummet below 50%. Ovarian cancer symptoms are vague and nonspecific, and current sc...
FW-HTF-T/Collaborative Research: Occupational Exoskeletons and the Human-Technology Partnership: Achieving Scale and Integration into the Future of Work
In multiple industrial sectors including manufacturing and construction, industrial exoskeleton technologies have substantial potential to improve productivity, and worker safety a...
MCA: Developing transcriptomics as a tool to investigate toxic diatom responses to ocean heatwave and upwelling events
The diatom Pseudo-nitzschia forms large, toxic harmful algal blooms along the U.S. West Coast, killing wildlife and harming valuable ocean fisheries. Understanding the causes of th...
SCC-PG: Planning for Resilience and Equity through Accessible Community Technology: Developing a Community-Led Planning Tool for Climate Readiness
PREACT (Planning for Resilience and Equity through Accessible Community Technology) is a multipurpose and multi-scalar climate preparedness and neighborhood planning software appli...
PA-21-071 for Pathea Bruno to CA260126-01 Identifying a proteomic signature for breast cancer detection in breast milk and serum
Program Director/Principal Investigator (Last, First, Middle): Darie, Costel C. Supplement Application (PAR-18-714) for Candidate Pathea Bruno Funded parent grant CA260126-01: Iden...
SCC-CIVIC-FA Track B: Artificial-Intelligence-Based Decision Support for Equitable and Resilient Food Distribution during Pandemics and Extreme Weather Events
Food insecurity is the lack of consistent and reliable access to nutritious food. In the Houston (Texas) area, over 14% of Harris County households experienced food insecurity befo...
SCC-IRG JST: PanCommunity: Leveraging Data and Models for Understanding and Improving Community Response in Pandemics
The goal of this integrative research effort is to enhance the understanding of the complex relationships characterizing pandemics and interventions under crisis. The global-scale...
Adapting Augmented Depression Therapy (ADepT) for treatment of first onset depression in young adults
People usually experience their first episode of depression between the ages of 14 and 24-years (13-14). Current NHS service-provision for first onset depression in young adults is...
Late-Stage C-H Iodination: Applications Towards Radiopharmaceutical Synthesis
Fluorine can be highly advantageous in pharmaceutical and agrochemical compounds as its presence can dramatically alter chemical and biological properties, including stability, lip...