Results for Health
130,725 grants found
Showing 126,901 – 126,920 of 130,725 grants for "Health"
Therapeutics targeting TDP-43 to treat Alzheimer's disease and related disorders
TDP-43 is a mixed proteinopapthy in Alzheimer’s disease (AD), AD-TDP, based on substantial epidemiological data correlating TDP-43 inclusions with cognitive decline in AD patients....
Transcriptional Regulators in Aging Macrophages
As key governors of tissue integrity, macrophages are implicated in many age-related diseases. Macrophages are a plastic myeloid immune cell type found in nearly every tissue of th...
Quantitative bone radiomics using Ultra-High Resolution CT
PROJECT SUMMARY / ABSTRACT Osteoporosis (OP) and osteoarthritis (OA) cumulatively affect more than 40 million Americans. Both OP and OA are underdiagnosed and undertreated because...
Vascular Effects on Astrocyte Functions in Young and Aging Brains
The brain is an incredibly energy-demanding organ, consuming ~20% of the total blood supply despite constituting only approximately 2% of body weight. Thus, the brain requires a co...
PRROPS: Pathways of Risk and Resilience for Overlapping Pain and Sensitization
Chronic pain affects >100 million American adults with estimated costs of up to $1 trillion annually. Older adults are at increased risk of having multiple painful conditions an...
PRROPS: Pathways of Risk and Resilience for Overlapping Pain and Sensitization
Chronic pain affects >100 million American adults with estimated costs of up to $1 trillion annually. Older adults are at increased risk of having multiple painful conditions an...
Racial Differences in Biomarkers and Therapeutic Targets for Chronic Itch
Itch, or pruritus, is a commonly reported symptom with over 7 million clinician visits annually in the United States. Indeed, the Global Burden of Disease Study by the World Health...
Collaborative Research: ERASE-PFAS: A "concentrate-and-destroy" technology for treating per- and polyfluoroalkyl substances using a new class of adsorptive photocatalysts
Per- and polyfluoroalkyl substances (PFAS) have been manufactured and widely used in hundreds of consumer products and industrial processes for decades. Release of PFAS into the en...
Collaborative Research: ERASE-PFAS: A "concentrate-and-destroy" technology for treating per- and polyfluoroalkyl substances using a new class of adsorptive photocatalysts
Per- and polyfluoroalkyl substances (PFAS) have been manufactured and widely used in hundreds of consumer products and industrial processes for decades. Release of PFAS into the en...
EAGER: Self-incompatibility in elderberry
Roughly half of the approximately 352,000 species of flowering plants on earth possess mechanisms that favor cross-pollination. This reproductive strategy is crucial for generating...
Post-Discharge Nephrology Follow-up for Improved Outcomes
PROJECT SUMMARY/ABSTRACT Acute kidney injury (AKI) is a common complication experienced by roughly 20% of adult patients during hospitalization. AKI is associated with long-term ad...
Behavioral and Pharmacological Treatments to Enhance Weight Outcomes after Metabolic and Bariatric Surgery
Project Summary. Rates of obesity and severe obesity are expected to continue to rise to alarming levels. By 2030, over 51% of adults in the US are expected to have obesity with a...
Behavioral and Pharmacological Treatments to Enhance Weight Outcomes after Metabolic and Bariatric Surgery
Project Summary. Rates of obesity and severe obesity are expected to continue to rise to alarming levels. By 2030, over 51% of adults in the US are expected to have obesity with a...
Post-Discharge Nephrology Follow-up for Improved Outcomes
PROJECT SUMMARY/ABSTRACT Acute kidney injury (AKI) is a common complication experienced by roughly 20% of adult patients during hospitalization. AKI is associated with long-term ad...
Behavioral and Pharmacological Treatments to Enhance Weight Outcomes after Metabolic and Bariatric Surgery
Project Summary. Rates of obesity and severe obesity are expected to continue to rise to alarming levels. By 2030, over 51% of adults in the US are expected to have obesity with a...
Post-Discharge Nephrology Follow-up for Improved Outcomes
PROJECT SUMMARY/ABSTRACT Acute kidney injury (AKI) is a common complication experienced by roughly 20% of adult patients during hospitalization. AKI is associated with long-term ad...
Racial Differences in Biomarkers and Therapeutic Targets for Chronic Itch
Itch, or pruritus, is a commonly reported symptom with over 7 million clinician visits annually in the United States.Indeed, the Global Burden of Disease Study by the World Health...
Chemical Biology of CFTR Regulation
SUMMARY Mutations that render the cystic fibrosis transmembrane conductance regulator (CFTR) defective in function lead to cystic fibrosis, a devastating multisystem disease affect...
A novel role for E2fs: E2f7 and E2f8 control motile ciliogenesis
ABSTRACT Multiciliated cells (MCCs) occur in airways, ependyma and oviduct and are crucial for respiration, neurogenesis and fertility. MCCs nucleate up to 300 motile cilia at thei...
PRROPS: Pathways of Risk and Resilience for Overlapping Pain and Sensitization
Chronic pain affects >100 million American adults with estimated costs of up to $1 trillion annually. Older adults are at increased risk of having multiple painful conditions an...