Results for Health
130,725 grants found
Showing 126,921 – 126,940 of 130,725 grants for "Health"
A novel role for E2fs: E2f7 and E2f8 control motile ciliogenesis
ABSTRACT Multiciliated cells (MCCs) occur in airways, ependyma and oviduct and are crucial for respiration, neurogenesis and fertility. MCCs nucleate up to 300 motile cilia at thei...
Polyamines drive glioblastoma progression
PROJECT SUMMARY Glioblastoma (GBM) is the most prevalent primary malignant brain tumor and is highly lethal with a median survival of approximately 20 months. GBM is incurable desp...
Targeting trained immunity and Th1/Th17 axis with combination adjuvants
PROJECT SUMMARY/ABSTRACT The lack of effective vaccines against most infectious diseases is largely a result of our fundamental lack of understanding of mechanisms involved in prot...
Targeting trained immunity and Th1/Th17 axis with combination adjuvants
PROJECT SUMMARY/ABSTRACT The lack of effective vaccines against most infectious diseases is largely a result of our fundamental lack of understanding of mechanisms involved in prot...
Acute effects and substitution feasibility of an oral nicotine pouch in smokeless tobacco users
Project Summary/Abstract Smokeless tobacco (SLT) exposes users to a variety of carcinogenic toxicants, yet nearly 6 million people in the US use SLT despite health risks.SLT contai...
University of Rochester Vaccine and Treatment Evaluation Unit (VTEU)
The Vaccine and Treatment Evaluation Units (VTEUs) are a critical resource for the NIAID Infectious Diseases Clinical Research Consortium to conduct clinical research and trials to...
Microstructural engineering of piezoelectric composites
This project will create novel fabrication approaches, using the freeze-casting method combined with slip- and tape-casting, to produce piezoelectric composites with microstructure...
Vagal REV-ERB as a Circadian Regulator of Satiation Signaling
Project Summary Obesity is an international epidemic with significant health and economic consequences. Excess caloric intake and dysregulated feeling of hunger/fullness largely co...
Characterization of the human antibody response to a novel neutralizing HIV-1 epitope
PROJECT SUMMARY The HIV pandemic is one of the most profound global human health challenges of our time, with 75 million people infected and 32 million dead from AIDS-related illne...
Role of repetitive element transcripts in brain aging and Alzheimer's disease
PROJECT SUMMARY The purpose of this NIH F32 training application is to provide support for Dr. Devin Wahl’s research and training that will prepare him to become an independent inv...
Metabolic Control of Proliferation and Differentiation in Oligodendrocytes
Project Summary Myelin is critical for proper brain function and its dysfunction, damage or inappropriate formation has been reported in a wide range of neurological and psychiatri...
A Rigorous Application of the RE-AIM Framework to Examine a Pediatric Obesity Intervention
PROJECT SUMMARY/ABSTRACT Pediatric obesity contributes to life-long chronic diseases and shortened life expectancy, making it a public health priority. Rural children have dispropo...
MRI Resource for Physiologic, Metabolic and Anatomic Biomarkers
SUMMARY The importance of biomarkers in clinical practice and regulatory science is difficult to overstate. The ultimate goal for clinical care of the future is to determine the mo...
MRI Resource for Physiologic, Metabolic and Anatomic Biomarkers
SUMMARY The importance of biomarkers in clinical practice and regulatory science is difficult to overstate. The ultimate goal for clinical care of the future is to determine the mo...
Quantitative bone radiomics using Ultra-High Resolution CT
PROJECT SUMMARY / ABSTRACT Osteoporosis (OP) and osteoarthritis (OA) cumulatively affect more than 40 million Americans. Both OP and OA are underdiagnosed and undertreated because...
Pharmacology & ImmunoPathology (PIP) Core
Pharmacology and Immunopathology Core – Hackensack Meridian Health ABSTRACT The pharmacology and ImmunoPathology Shared Resource Core will serve the Projects and the Clinical Core...
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
Project Summary/Abstract There is growing societal and scientific interest in using genomic sequencing (GS) as screening to identify genetic predispositions for disease early in li...
Transcriptional Regulators in Aging Macrophages
As key governors of tissue integrity, macrophages are implicated in many age-related diseases. Macrophages are a plastic myeloid immune cell type found in nearly every tissue of th...
Defining mechanisms of perianal fistula inception in African and European ancestry Crohn's disease patients
PROJECT SUMMARY Crohn’s disease (CD) is characterized by progressive, transmural inflammation that can affect any region of the gastrointestinal tract. Penetrating complications, m...
ROS Mechanisms in BAV Aortopathy
PROJECT SUMMARY Ascending aortic aneurysmal disease is a major worldwide health problem. Bicuspid aortic valve (BAV)- associated aortopathy represents the largest subset of affecte...