Results for Health
130,725 grants found
Showing 126,961 – 126,980 of 130,725 grants for "Health"
Therapeutics targeting TDP-43 to treat Alzheimer's disease and related disorders
TDP-43 is a mixed proteinopapthy in Alzheimer’s disease (AD), AD-TDP, based on substantial epidemiological data correlating TDP-43 inclusions with cognitive decline in AD patients....
Characterization of the human antibody response to a novel neutralizing HIV-1 epitope
PROJECT SUMMARY The HIV pandemic is one of the most profound global human health challenges of our time, with 75 million people infected and 32 million dead from AIDS-related illne...
Quantitative bone radiomics using Ultra-High Resolution CT
PROJECT SUMMARY / ABSTRACT Osteoporosis (OP) and osteoarthritis (OA) cumulatively affect more than 40 million Americans. Both OP and OA are underdiagnosed and undertreated because...
Utilizing Human Brain Organoids to Model the Differential Effects of SCN8A Mutation on Cortex and Hippocampus
Project Summary/Abstract Epilepsy is a severe and debilitating disease and a significant public health concern. Epilepsy is also a disease without a medical cure, and a disease whe...
Genetics & Genomics Training Program
This application is a request for support for the Predoctoral Training Program in Genetics & Genomics at Baylor College of Medicine. This Program started in 1987 and has been f...
Therapeutics targeting TDP-43 to treat Alzheimer's disease and related disorders
TDP-43 is a mixed proteinopapthy in Alzheimer’s disease (AD), AD-TDP, based on substantial epidemiological data correlating TDP-43 inclusions with cognitive decline in AD patients....
MRI Resource for Physiologic, Metabolic and Anatomic Biomarkers
SUMMARY The importance of biomarkers in clinical practice and regulatory science is difficult to overstate. The ultimate goal for clinical care of the future is to determine the mo...
Chronic Versus Acute Transplantation of Neural Tissues for TBI-Induced Cortical Injuries
PROJECT SUMMARY/ABSTRACT Injury to the cerebral cortex occurs frequently across the spectrum of severity in traumatic brain injury (TBI). No therapies exist to counter the neurolog...
ThGM Cells in CNS Autoimmunity
SUMMARY ThGM Cells in CNS Autoimmunity ThGM cells (ThGM-CSF) are a newly described Th subset characterized by production of GM-CSF, but lacking expression of signature cytokines an...
Synthetic biology and organelle genomics: A rubisco library as a case study in evolutionary landscapes and organellar engineering
Food security is a critical issue facing human health in the 21st century as the global population approaches 10 billion and climate change threatens the food supply.Photosynthetic...
Development and Evaluation of Novel Aptamer-based Therapeutics Targeting SARS-CoV-2 in a Physiologically-Relevant Model of Human Airway Epithelium
The impact of SARS-CoV-2 on public health and the global economy cannot be overstated. As of September 28, 2020, 33,224,222 cases and 999,298 deaths worldwide have been linked to t...
ThGM Cells in CNS Autoimmunity
SUMMARY ThGM Cells in CNS Autoimmunity ThGM cells (ThGM-CSF) are a newly described Th subset characterized by production of GM-CSF, but lacking expression of signature cytokines an...
ThGM Cells in CNS Autoimmunity
SUMMARY ThGM Cells in CNS Autoimmunity ThGM cells (ThGM-CSF) are a newly described Th subset characterized by production of GM-CSF, but lacking expression of signature cytokines an...
Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design
PROJECT SUMMARY/ABSTRACT Background: Male sex workers (MSWs), or men who exchange sex for money, goods, drugs, or other items of value with other men, are at exceptionally high ris...
Development of a therapeutic bacterial consortium for constipation
The goal of the proposed project is to develop a probiotic for the treatment of constipation, comprised of 2-3 anti- inflammatory strains of human gut-derived bacteria that enhance...
Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design
PROJECT SUMMARY/ABSTRACT Background: Male sex workers (MSWs), or men who exchange sex for money, goods, drugs, or other items of value with other men, are at exceptionally high ris...
The Anatomy of Firm Exit: Theory and Facts
Firm exit is a significant contributor to overall job destruction. In addition to the jobs lost, firm exit permanently destroys intangible capital, such as customer-firm relationsh...
Targeting trained immunity and Th1/Th17 axis with combination adjuvants
PROJECT SUMMARY/ABSTRACT The lack of effective vaccines against most infectious diseases is largely a result of our fundamental lack of understanding of mechanisms involved in prot...
Polyamines drive glioblastoma progression
PROJECT SUMMARY Glioblastoma (GBM) is the most prevalent primary malignant brain tumor and is highly lethal with a median survival of approximately 20 months. GBM is incurable desp...
University of Rochester Vaccine and Treatment Evaluation Unit (VTEU)
The Vaccine and Treatment Evaluation Units (VTEUs) are a critical resource for the NIAID Infectious Diseases Clinical Research Consortium to conduct clinical research and trials to...