Results for Health
130,725 grants found
Showing 127,121 – 127,140 of 130,725 grants for "Health"
Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice care
ABSTRACT The goal of this Mentored Career Development Award is to prepare Dr. Lauren Gerlach for a career as an independent investigator focused on measuring and improving the qual...
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron. There are over two thousand proteins encoded by the human genome that contain zinc b...
Neurodevelopment after postnatal Zika virus infection in infant macaques
PROJECT SUMMARY / ABSTRACT Intense research has focused on the neurologic effects of prenatal Zika virus (ZIKV) infection; however, the consequences of postnatal infection early in...
Elucidating the role and mechanisms by which collagenase producing intestinal bacteria promote colorectal cancer recurrence and metastasis following surgery.
PROJECT SUMMARY / ABSTRACT Colorectal cancer (CRC) is a major health concern with nearly 2-million new cases of CRC diagnosed worldwide in 2019. While surgical resection of the pri...
Neurodevelopment after postnatal Zika virus infection in infant macaques
PROJECT SUMMARY / ABSTRACT Intense research has focused on the neurologic effects of prenatal Zika virus (ZIKV) infection; however, the consequences of postnatal infection early in...
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
Project Abstract The overall theme of my research program is to understand the formation mechanism of chromatin structure and its role in gene regulation. We plan to address this p...
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures
PROJECT SUMMARY Early detection of lung cancer among asymptomatic individuals is a priority for reducing mortality of the number one cancer killer worldwide. Most lung cancers are...
Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice care
ABSTRACT The goal of this Mentored Career Development Award is to prepare Dr. Lauren Gerlach for a career as an independent investigator focused on measuring and improving the qual...
Enabling Mass Spectrometry Analysis of the Sulfoproteome
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in eukar...
CAREER: Big Computation and the Management of Emerging Infectious Diseases
Emerging infectious diseases (EIDs) account for more than 25% of global disease burden and more than 32% of global deaths. Current EIDs like Middle East Respiratory Syndrome Corona...
The role of Bik in the replication and severity of influenza A virus
Influenza A virus (IAV) is responsible for seasonal epidemics that results in severe respiratory illness and deaths worldwide, costing billions of dollars annually in the U.S. alon...
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
Project Abstract The overall theme of my research program is to understand the formation mechanism of chromatin structure and its role in gene regulation.We plan to address this pr...
Complexity and the Wound Healing Response
Project Summary The ability to heal is essential for human health. The remarkable wound healing capacity of humans (and indeed of all animals) is a complicated process.Genomic stud...
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron.There are over two thousand proteins encoded by the human genome that contain zinc bi...
Elucidating the role and mechanisms by which collagenase producing intestinal bacteria promote colorectal cancer recurrence and metastasis following surgery.
PROJECT SUMMARY / ABSTRACT Colorectal cancer (CRC) is a major health concern with nearly 2-million new cases of CRC diagnosed worldwide in 2019.While surgical resection of the prim...
Novel Immunoregulatory Therapeutics for Systemic Lupus Erythematosus
Novel Immunoregulatory Drugs for Systemic Lupus Erythematosus BioTherapeutics, Inc (BTI) is an emerging biotech company that synergistically combines the power of advanced computat...
Population-Targeted Risk Prediction to Guide Breast Cancer Screening in Cameroon
Project Summary/Abstract: As cancer becomes an increasingly important cause of mortality in sub-Saharan Africa, nations must improve their capacity to diagnose and treat the malign...
Humanization of ACE2 and Associated Priming Proteases in New Mouse Models for Downstream Disease and Therapy Investigations of COVID-19
With the initial wave of zoonotic transmission firmly established in the human population worldwide, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) poses an e...
Development and Testing of a Mobile Application to Enhance HIV Prevention Cascade in Malaysian MSM
Abstract Malaysia?s HIV epidemic is rapidly expanding with recent evidence suggesting accelerated sexual transmission, especially in MSM: 10% in 2008 to 54% in 2016. Evidence sugge...
Enabling Mass Spectrometry Analysis of the Sulfoproteome Supplement
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in eukar...