Results for Health
130,725 grants found
Showing 127,161 – 127,180 of 130,725 grants for "Health"
Transcriptional profiling of nutritional deficiency in single neurons: insights for state-dependent behaviour and healthy ageing
BACKGROUNDThe function of our nervous system is intimately connected to our diet. Our brain constantly evaluates energy and nutrient levels in our bodies to make us eat when hungry...
Investigation and application of hydrocarbon-degrading enzymes using cryo-electron microscopy and directed evolution
PROJECT SUMMARY Glycyl radical enzymes (GREs) are a growing superfamily that catalyzes an impressive array of chemical transformations critical to both human health and the environ...
Investigation and application of hydrocarbon-degrading enzymes using cryo- electron microscopy and directed evolution
PROJECT SUMMARY Glycyl radical enzymes (GREs) are a growing superfamily that catalyzes an impressive array of chemical transformations critical to both human health and the environ...
StEP OUT
PROJECT SUMMARY/ABSTRACT This Mentored Patient-Oriented Research Career Development Award (K23) proposal will address an urgent need to advance the science of child obesity prevent...
How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - Renewal
ABSTRACT The plasticity and functional diversity of regulatory T cells (Tregs) is essential for the maintenance of healthy immunity but it is also exploited in disease. We have des...
CAREER: Modeling Genetic Variation Using Deep Generative Neural Networks
The cost of genome sequencing has decreased by orders of magnitude over the past two decades, enabling the creation of datasets comprised of up to millions of genomes of plants, an...
CAREER: Network Centrality and Its Applications in Detection, Dynamics, and Load Balancing
This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). This project aims to develop a mathematical understanding of networks that e...
Conference: 2022 Meeting of the Pan-American Society for Evolutionary Developmental Biology (Vancouver, Canada July 17-20, 2022)
Evolutionary Developmental Biology (EvoDevo) is an integrative field that sits at the intersection of Evolutionary Biology, Developmental Biology, Genetics, Genomics, and Physiolog...
EPSRC-SFI: Cutting Edge Analytical Solutions for Smart, Integrated, Efficient Biopharmaceutical Production
There was a time when small molecules dominated the pharmaceutical market for the treatment of diseases like cancer as well as bacterial, fungal and viral infections. However, over...
FET: III: Small: Innovative Approaches for Bias Correction and Systems-level Analysis in Integrated Multi-omics Data
Identifying impacted pathways and changes in biological processes is important because it provides insights into the biology underlying conditions beyond the detection of different...
Effect of pericyte stimulation on traumatic brain injury pathophysiology
Brain vascular pericytes are an essential component of the neurovascular unit and perform a number of diverse functions in regulating brain homeostasis. A common feature of many ne...
Chemical Reactivity and Redox Behavior of Heme-HNOx Derivatives
In this project, funded by the Chemical Structure, Dynamics, and Mechanism B Program of the Division of Chemistry, Professor George Richter-Addo of the Department of Chemistry and...
Collaborative Research: Elucidating the Coupling of Inorganic Scaling and Organic Fouling in Reverse Osmosis Desalination: An Integrated Experimental and Computational Approach
Climate change and anthropogenic pollution are contributing to the increasing scarcity of freshwater resources in many regions around the globe. In the United States, water stress...
High performance wearable body odor sensor arrays for disease detection and monitoring
Project Summary Many diseases, both internal and cutaneous, have distinct odors associated with them, and their identification can provide unique diagnostic clues, guide laboratory...
Improving medication adherence using a CONnected CUstomized Treatment Platform (CONCURxP)
PROJECT SUMMARY Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) nearly doubles progression-free survival and increases overall survival when added to endocrine therapy in hormone...
Cardiovascular disease in fetal alcohol spectrum disorder
Project Summary The incidence of congenital heart defects (CHDs) and cardiovascular disease (CVD) in patients with fetal alcohol spectrum disorder (FASD) are poorly characterized....
Testing Effective Methods to Recruit Sexual and Gender Minority Cancer Patients for Cancer Studies
Abstract Recently, NCI called for research to effectively study small or rare populations relevant to cancer research. Sexual and gender minorities (SGM) are small populations at d...
Pharmacotherapy in conjunction with lifestyle counseling for management of weight regain after bariatric surgery (PROJECT-BARI)
Project Summary Although bariatric surgery is the most effective treatment for severe obesity, a large proportion of patients experience significant weight regain with longer follo...
Evaluation of the SCALED (SCaling AcceptabLE cDs) Approach for the Implementation of Interoperable CDS for Venous Thromboembolism Prevention
ABSTRACT/PROJECT SUMMARY There is a global emphasis and critical need to close the patient-centered outcomes research (PCOR) evidence to practice gap. Forty percent of patients do...
Discovery and manipulation of transcription factors to restore long term stem cell repopulation in aged bone-marrow
Project Summary Aging has a complex underlying biology characterized by a progressive loss of cellular and physiological function and this deterioration is strongly correlated with...