Results for Health
130,725 grants found
Showing 127,261 – 127,280 of 130,725 grants for "Health"
Platelet-mediated mechanisms of placental and systemic hypercoagulability in preeclampsia
PROJECT SUMMARY/ABSTRACT Preeclampsia (PE) remains a significant clinical and public health burden affecting 3-5% of all pregnancies worldwide, and is a leading cause of maternal a...
ULTRA-SPEED ATOMIC FORCE MICROSCOPY FOR CRYSTALLISATION
Crystals have provided fascination and utility to man since the dawn of time taking an important place in ancient civilisations with talismanic properties or as the functional quar...
55th Annual Meeting of the Society for Leukocyte Biology
PROJECT SUMMARY/ABSTRACT This proposal is to request support for the 55th Annual Meeting of the Society For Leukocyte Biology entitled: “Leukocytes on the Wave for Translating Medi...
Development of Broad-Spectrum Cyclic Amphiphilic Peptides against Multidrug-Resistant Bacteria
ABSTRACTThe emergence of antibacterial resistance to common frontline antibiotics, such as methicillin, vancomycin, cephalosporins,and carbapenem, have created a global public heal...
Single arm trial of menstrual cups among economically vulnerable women to reduce Bacterial vaginosis and STIs through reduced harmful sexual and menstrual practices
In western Kenya, HIV prevalence is 16% among women in the general population, and 29% among the most economically constrained women. The HIV/STI epidemic overlaps with broader rep...
CAREER: Testing the mismatch hypothesis for climate change-driven mutualism breakdown
In the mutually beneficial interaction between flowering plants and pollinators, plants benefit from pollen transfer among flowers, and pollinators benefit from nutrition in the fo...
Structural Racism, Resilience, and Premature Cognitive Aging in End-Stage Renal Disease - Revision - 5
ABSTRACT Only 13% of the 780,000 adults living with end-stage renal disease (ESRD) have normal cognitive function. We found that 14.0% of ESRD patients aged 35-49 experience severe...
Contribution of chromosome versus gonadal sex to bone mass and strength
SUMMARY Alzheimer's disease (AD) is a growing health concern and is the most common type of dementia worldwide, affecting women with higher frequency. Evidence indicates that...
Structural Racism, Resilience, and Premature Cognitive Aging in End-stage Renal Disease
ABSTRACT Only 13% of the 780,000 adults living with end-stage renal disease (ESRD) have normal cognitive function. We found that 14.0% of ESRD patients aged 35-49 experience severe...
Mitochondrial quality control in the heart
PROJECT SUMMARY Adult cardiomyocytes (CMs) are critically dependent on the proper function of mitochondria to supply the fuel for contraction (ATP) and to regulate other essential...
Structural Racism, Resilience, and Premature Cognitive Aging in End-stage Renal Disease
ABSTRACT Only 13% of the 780,000 adults living with end-stage renal disease (ESRD) have normal cognitive function. We found that 14.0% of ESRD patients aged 35-49 experience severe...
Quantifying and Understanding Glaucoma Eye Drop Medication Instillation and Adherence
PROJECT ABSTRACT Despite the availability of effective treatments, glaucoma remains the leading cause of irreversible blindness among African American adults and the second leading...
Effect of pericyte stimulation on traumatic brain injury pathophysiology
Brain vascular pericytes are an essential component of the neurovascular unit and perform a number of diverse functions in regulating brain homeostasis. A common feature of many ne...
Staphylococcus aureus SPREAD (S. aureus Study of Prevalence Resistance and Environmental Dissemination)
PROJECT SUMMARY Staphylococcus aureus is a bacterial species that causes infections of the skin, lungs, blood and internal organs. These infections can have their onset in the comm...
Cancer Genomics and Genomic Data Science for East Africa
PROJECT SUMMARY/ABSTRACT The 20-years since publication of the draft human genome sequence in 2001 have been a truly transformational era in the field of cancer research marked by...
Nonlipogenic ABCA1 inducers for ADRD
Alzheimer's disease and related dementia (ADRD) constitutes a growing health crisis. Equally, chronic metabolic diseases such as type 2 diabetes (T2D) are increasing, because...
Investigation and application of hydrocarbon-degrading enzymes using cryo-electron microscopy and directed evolution
PROJECT SUMMARY Glycyl radical enzymes (GREs) are a growing superfamily that catalyzes an impressive array of chemical transformations critical to both human health and the environ...
Examining how the novel S64F MAFA variant produces glucose intolerance or hypoglycemia in a sex-dependent manner
PROJECT ABSTRACT As of 2018, 30.3 million Americans have been diagnosed with diabetes (10% of the U.S. population with a male sex bias). Its close associations with many chronic di...
A novel psychological-behavioral intervention to promote physical activity in type 2 diabetes.
Among the 30 million Americans with type 2 diabetes (T2D), physical activity is prospectively associated with better glycemic control, reduced cardiovascular risk, and lower rates...
Investigating the molecular details of assembly, disassembly and trafficking of GPCR-arrestin complexes
Project Summary: Mis-regulation of G protein-coupled receptor (GPCR) trafficking and signaling is implicated in causing several diseases and the development of drug tolerance, havi...