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Results for Health

130,725 grants found

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Showing 127,681127,700 of 130,725 grants for "Health"

Active NON-SBIR/STTR RPGS
Regulation of Osteocyte Survival by Fibroblast Growth Factor Signaling Pathways
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETA... Washington University United States 2022 – 2027

Regulation of Osteocyte Survival by Fibroblast Growth Factor Signaling Pathways Summary Osteocyte death, one of the hallmarks of skeletal aging, contributes to the age-related decl...

$5.24M
USD
Active NON-SBIR/STTR RPGS
Regulation of Osteocyte Survival by Fibroblast Growth Factor Signaling Pathways
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETA... Washington University United States 2022 – 2027

Regulation of Osteocyte Survival by Fibroblast Growth Factor Signaling Pathways Summary Osteocyte death, one of the hallmarks of skeletal aging, contributes to the age-related decl...

$5.24M
USD
Active NON-SBIR/STTR RPGS
Regulation of Osteocyte Survival by Fibroblast Growth Factor Signaling Pathways
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETA... Washington University United States 2022 – 2027

Regulation of Osteocyte Survival by Fibroblast Growth Factor Signaling Pathways Summary Osteocyte death, one of the hallmarks of skeletal aging, contributes to the age-related decl...

$5.08M
USD
Completed NON-SBIR/STTR RPGS
Functional Characterization of Egyptian rousette Bat Innate immune synapses
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... Icahn School of Medicine At Mount Sinai United States 2022 – 2024

The long-term goal is to characterize the cellular and molecular constituents of the bat immune system. Our group had been working on Marburg virus (MARV) spillover and transmissio...

$2.11M
USD
Completed NON-SBIR/STTR RPGS
Bioactive Components in Breast Milk Impact Rotavirus Vaccine Response
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... Baylor College of Medicine United States 2022 – 2025

PROJECT SUMMARY Despite the introduction of live attenuated oral rotavirus vaccines (ORVs) in over 100 countries, rotavirus (RV) remains the leading cause of acute gastroenteritis...

$2.48M
USD
Active RESEARCH CENTERS
Clinical Imaging and Data Resources Core
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES University of Oklahoma United States 2022 – 2026

ABSTRACT – Clinical Imaging and Data Resources Core The overarching objective of this Clinical Imaging and Data Resources Core (CIDRC) is to provide research project leaders (RPLs)...

Completed TRAINING, INDIVIDUAL
Hyperphosphatemia Contributes to Cardiac Injury in Chronic Kidney Disease
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of Alabama At Birmingham United States 2022 – 2025

PROJECT SUMMARY Chronic kidney disease (CKD) is a health epidemic that increases risk of death due to cardiovascular disease. Hyperphosphatemia and elevations in serum levels of th...

$489.7K
USD
Completed NON-SBIR/STTR RPGS
The impact of genomic variation on environment-induced changes in pancreatic beta cell states
NATIONAL HUMAN GENOME RESEARCH INSTITUTE University of California, San Diego United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Pancreatic beta cells secrete insulin in order to maintain blood glucose homeostasis.Insulin secretion is tightly regulated by glucose and modulated by num...

$12.8M
USD
Completed NON-SBIR/STTR RPGS
The impact of genomic variation on environment-induced changes in pancreatic beta cell states
NATIONAL HUMAN GENOME RESEARCH INSTITUTE University of California, San Diego United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Pancreatic beta cells secrete insulin in order to maintain blood glucose homeostasis. Insulin secretion is tightly regulated by glucose and modulated by nu...

$12.8M
USD
Completed NON-SBIR/STTR RPGS
The impact of genomic variation on environment-induced changes in pancreatic beta cell states
NATIONAL HUMAN GENOME RESEARCH INSTITUTE University of California, San Diego United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Pancreatic beta cells secrete insulin in order to maintain blood glucose homeostasis. Insulin secretion is tightly regulated by glucose and modulated by nu...

$12.8M
USD
Completed NON-SBIR/STTR RPGS
The impact of genomic variation on environment-induced changes in pancreatic beta cell states
NATIONAL HUMAN GENOME RESEARCH INSTITUTE University of California, San Diego United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Pancreatic beta cells secrete insulin in order to maintain blood glucose homeostasis. Insulin secretion is tightly regulated by glucose and modulated by nu...

$12.54M
USD
Completed NON-SBIR/STTR RPGS
Beneficial effects of childhood vaccines for prevention of type 1 diabetes, autoimmune thyroid disease, and celiac disease
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of Michigan At Ann Arbor United States 2021 – 2023

Viral infections have long been hypothesized to be triggers for childhood autoimmune conditions, but the benefit of childhood vaccines for prevention of such diseases is uncertain....

$2.34M
USD
Completed NON-SBIR/STTR RPGS
Beneficial effects of childhood vaccines for prevention of type 1 diabetes, autoimmune thyroid disease, and celiac disease
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of Michigan At Ann Arbor United States 2021 – 2023

Viral infections have long been hypothesized to be triggers for childhood autoimmune conditions, but the benefit of childhood vaccines for prevention of such diseases is uncertain....

$1.95M
USD
Active NON-SBIR/STTR RPGS
Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's disease
NATIONAL INSTITUTE ON AGING University of Southern California United States 2021 – 2026

PROJECT SUMMARY Perivascular spaces (PVS) are the area around arterioles, venules and capillaries which accommodate the clearance of the metabolic waste via Aquaporin-4 channels ex...

$8.24M
USD
Active NON-SBIR/STTR RPGS
Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's disease
NATIONAL INSTITUTE ON AGING University of Southern California United States 2021 – 2026

PROJECT SUMMARY Perivascular spaces (PVS) are the area around arterioles, venules and capillaries which accommodate the clearance of the metabolic waste via Aquaporin-4 channels ex...

$8.24M
USD
Completed NON-SBIR/STTR RPGS
A planning project to pilot test and optimize dietary approaches to slow aging and design a long-term trial
NATIONAL INSTITUTE ON AGING Lsu Pennington Biomedical Research Ctr United States 2021 – 2025

PROJECT SUMMARY The world's population is aging in an obesogenic environment characterized by increased availability of high caloric, non-nutritious foods and reduced needs fo...

$10.27M
USD
Completed TRAINING, INDIVIDUAL
Common Genetic Variation of Vitamin D Binding Protein and Vitamin D Kinetics
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of Washington United States 2021 – 2022

PROJECT SUMMARY/ABSTRACT Vitamin D binding protein (DBP) stabilizes circulating concentrations of vitamin D metabolites and modulates their delivery to tissues. Many observational...

$626.7K
USD
Completed NON-SBIR/STTR RPGS
A planning project to pilot test and optimize dietary approaches to slow aging and design a long-term trial
NATIONAL INSTITUTE ON AGING Lsu Pennington Biomedical Research Ctr United States 2021 – 2024

PROJECT SUMMARY The world's population is aging in an obesogenic environment characterized by increased availability of high caloric, non-nutritious foods and reduced needs fo...

$10.72M
USD
Completed NON-SBIR/STTR RPGS
Combining information from multiple circadian activity rhythm metrics to optimally detect mild cognitive impairment using a consumer wearable
NATIONAL INSTITUTE ON AGING University of Pittsburgh At Pittsburgh United States 2021 – 2023

Abstract: Widely-scalable methods for the earlier detection of elevated Alzheimer?s Disease and Related Dementia (ADRD) would enable earlier intervention and can help reduce/delay...

$2.45M
USD
Active NON-SBIR/STTR RPGS
Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's disease
NATIONAL INSTITUTE ON AGING University of Southern California United States 2021 – 2026

PROJECT SUMMARY Perivascular spaces (PVS) are the area around arterioles, venules and capillaries which accommodate the clearance of the metabolic waste via Aquaporin-4 channels ex...

$8.24M
USD