Results for Health
130,725 grants found
Showing 127,721 – 127,740 of 130,725 grants for "Health"
A multiscale approach for elucidating nuclear entry mechanisms of HIV-1 capsid
Project Summary Human immunodeficiency virus type 1 (HIV-1) remains a major threat to global health. Therefore, it is essential that we fully understand the mechanism of viral infe...
A multiscale approach for elucidating nuclear entry mechanisms of HIV-1 capsid
Project Summary Human immunodeficiency virus type 1 (HIV-1) remains a major threat to global health. Therefore, it is essential that we fully understand the mechanism of viral infe...
Constrained Disentanglement (CODE) Network for CT Metal Artifact Reduction in Radiation Therapy
?ABSTRACT The World Health Organization reported that cancer is the second leading cause of death globally and is re- sponsible for 9.6 million deaths in 2018. Approximately 50% of...
Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa
Project Summary/Abstract Sickle cell anemia (SCA) is among the world?s most common and devastating blood disorders, affecting more than 300,000 newborns per year.The majority of in...
A Squirrel Monkey Model of Alzheimer’s Disease: Developing Behavioral, Blood, and CSF Biomarkers
Project Summary Alzheimer?s disease (AD) is a major health concern defined by pathologic changes in the brain that produce altered behavior and cognitive function.There is a need f...
Impact of Music Improvisation Training on Brain Function and Cognition among Older Adults
ABSTRACT Approximately 5.8 million adults age 60 and over in the United States live with Alzheimer disease and related dementias (AD/ADRD) at a cost of $290 billion per year.Older...
Development of Memesto, a wearable repetitive message and music therapy device that senses and reduces agitation in persons with AD/ADRD.
PROJECT SUMMARY Alzheimer?s Disease and Related Dementias (AD/ADRD) are age-associated neuro-degenerative diseases characterized by memory loss, disorientation, and reduced decisio...
Clinical and immunologic factors underlying heart failure with preserved ejection fraction among persons with HIV in South Africa
Premise: HIV associated CVD is a significant cause of clinical morbidity and a barrier to successful aging among persons living with HIV (PWH). To date, HIV-CVD research has emphas...
Identification of Precision Sepsis Subphenotypes Using Vital Sign Trajectories
Project Abstract The scientific goal of this K23 is to apply cutting-edge data science approaches to identify novel subphenotypes within the heterogeneous sepsis syndrome. This K23...
Clinical and immunologic factors underlying heart failure with preserved ejection fraction among persons with HIV in South Africa
Premise: HIV associated CVD is a significant cause of clinical morbidity and a barrier to successful aging among persons living with HIV (PWH). To date, HIV-CVD research has emphas...
The Behavioral Determinants of Metabolic Syndrome Risk Development in Young Adults
PROJECT SUMMARY / ABSTRACT As few as 23.3% of U.S. young adults 20-years and up are considered metabolically healthy, based on the absence of all traditional metabolic syndrome (Me...
Role of estrogen receptor-a in aging and sex-specific responses to 17a-estradiol
PROJECT SUMMARY/ABSTRACT Several pharmacological compounds have shown promise as interventional strategies for extending longevity.One recently studied compound shown to improve he...
Trial of Statins for Chemoprevention in Hepatocellular Carcinoma
PROJECT SUMMARY Worldwide, hepatocellular carcinoma (HCC) represents the fifth most common cancer and the second-leading cause of cancer-related mortality. In the U.S., both the HC...
Brainstem circuitry for sleep-wake control
PROJECT SUMMARY/ABSTRACT It is now clear that poor sleep quality has dramatic health consequences, yet sleep medicine is still in great need for safe and efficient sleep aids.Recen...
Neurocognition and Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, affecting 1%-3% of the general population, with greater prevalence in older persons (8%-10%).AF is associa...
Towards biomarkers of resiliency in the extremely preterm child: a multimodal neuroimaging study of brain and environment
Prematurity is a public health crisis impacting 10% of all births. There is significant risk for neurocognitive impairment, including language. This can adversely impact quality of...
Dissecting the role of neuronal-astroglial interactions in sleep homeostasis
PROJECT SUMMARY Insufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common in the United States.Many sleep disorders may be assoc...
Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables
Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables Project Summary/Abstract Research: Heart failure is one of the leading caus...
A Fully Decentralized Federated Learning Framework for Automated Image Segmentation in Cancer Radiotherapy
PROJECT SUMMARY While the recent surge of artificial intelligence (AI) has made remarkable progress in various image analysis tasks, their performance in a broad range of clinical...
Global significance test based on quantile regression with applications to genomic studies of Alzheimer’s disease
Project Summary/Abstract Alzheimer's disease (AD) is one of the leading causes of death for the elderly with no current cure.Genomics studies, such as mapping expression quant...