Results for Health
130,725 grants found
Showing 127,801 – 127,820 of 130,725 grants for "Health"
Role of Zika virus (ZIKV) infection in glaucoma pathobiology
PROJECT SUMMARY The overall goal of this project is to investigate the role of Zika virus (ZIKV) in glaucoma pathobiology. ZIKV is an emerging viral pathogen that causes microcepha...
Scaling up tobacco control in India: Comparing smartphone to in-person training for implementing an evidence-based intervention to reduce tobacco use among schoolteachers
Project Summary: Tobacco-related deaths are rising rapidly in low and middle-income countries (LMICs). In India alone, tobacco use accounts for over 1.2 million deaths each year. R...
Targeting added sugar to improve dietary intake in high-risk adolescents
PROJECT ABSTRACT The overall goal of this K01 proposal is to provide Gina Tripicchio, PhD, MSEd, with the training and mentorship to establish an independent program of research fo...
Trial of Statins for Chemoprevention in Hepatocellular Carcinoma
PROJECT SUMMARY Worldwide, hepatocellular carcinoma (HCC) represents the fifth most common cancer and the second-leading cause of cancer-related mortality. In the U.S., both the HC...
In Situ Tumor Vaccination with a Nano-oligo Therapeutic to Induce Whole-body Antitumor Immune Response
Significance/Goal.Although immune checkpoint inhibitors (ICIs) have shown impressive outcomes in melanoma patients, the majority of patients fail to respond, mainly due to the abse...
Role of estrogen receptor-a in aging and sex-specific responses to 17a-estradiol
PROJECT SUMMARY/ABSTRACT Several pharmacological compounds have shown promise as interventional strategies for extending longevity. One recently studied compound shown to improve h...
Scaling up tobacco control in India: Comparing smartphone to in-person training for implementing an evidence-based intervention to reduce tobacco use among schoolteachers
Project Summary: Tobacco-related deaths are rising rapidly in low and middle-income countries (LMICs). In India alone, tobacco use accounts for over 1.2 million deaths each year. R...
Towards biomarkers of resiliency in the extremely preterm child: a multimodal neuroimaging study of brain and environment
Prematurity is a public health crisis impacting 10% of all births. There is significant risk for neurocognitive impairment, including language. This can adversely impact quality of...
Mapping the Time Course of mTORC1-Driven Tumorigenesis in the Developing Brain
SUMMARY The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway regulates cell size and growth and is frequently mutated in disease, including in a class of neurodev...
Structure and Functionof a Parasitic TGF-beta Mimic, TGM
Project Summary Helminth parasites are a threat to global health, with nearly one-third of the world?s population currently infected, constituting a high disease burden amongst bot...
Combating Highly Aggressive Prostate Cancer: Development of Novel Patient Derived Xenograft Models and Application in Preclinical Studies of Novel Selective Androgen Receptor Degraders
Project Summary Disparities in cancer incidence, prevalence, mortality and survivorship burden racial and ethnic minority populations in the US. In addition, these minority populat...
Fibrinolysis Dysfunction Impact on Graft Function in Liver Transplantation
PROJECT SUMMARY/ABSTRACT This is an application for a K99 award for Dr. Hunter Moore, a transplant surgery fellow at the University of Colorado School of Medicine. Dr.Moore is esta...
Drug Overdose Testing: A Data Collection and Reporting Emergency
The overdose epidemic is driven by illicit fentanyl and fentanyl analogues, often combined with synthetic simulants.The addition of new psychoactive substances (NPS), a broad class...
Efficacy of a self-advocacy serious game intervention for women with advanced cancer
Project Summary Individuals with cancer must overcome multiple, ongoing challenges (“self-advocate”) related to their cancer experience to receive patient-centered care. Women with...
Dissecting the role of neuronal-astroglial interactions in sleep homeostasis
PROJECT SUMMARY Insufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common in the United States. Many sleep disorders may be asso...
In Situ Tumor Vaccination with a Nano-oligo Therapeutic to Induce Whole-body Antitumor Immune Response
Significance/Goal.Although immune checkpoint inhibitors (ICIs) have shown impressive outcomes in melanoma patients, the majority of patients fail to respond, mainly due to the abse...
South Texas Alzheimer's Disease Center Clinical Core
Abstract The Mexican-American (MA) Hispanic community is the most rapidly growing minority and is disproportionately affected by Alzheimer’s disease and related dementias (ADRDs)....
HOPE in Action: A Clinical Trial of HIV-to-HIV Liver Transplantation
End-stage liver disease is common in HIV-infected (HIV+) individuals due to co-infection with hepatitis C virus (HCV), hepatitis B virus (HBV), and alcoholic and non-alcoholic fatt...
Targeting added sugar to improve dietary intake in high-risk adolescents
PROJECT ABSTRACT The overall goal of this K01 proposal is to provide Gina Tripicchio, PhD, MSEd, with the training and mentorship to establish an independent program of research fo...
Cardiovascular Consequences of Duchenne and Becker Muscular Dystrophinopathies
ABSTRACT/PROJECT SUMMARY Duchenne and Becker muscular dystrophinopathies (DMD/BMD) have a mutation in the dystrophin gene that, together, represent over 80% of all cases of muscula...