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Transcriptional control of NK cell metabolism
Project Summary Natural killer (NK) cells comprise an important arm of the host innate immune system that detects and eliminates virus-infected cells. Newborns and immune-compromis...
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity
PROJECT SUMMARY Of the greater than 350 Primary Immunodeficiency Diseases (PID) in humans that have been identified to date, the molecular basis of a significant number (~100) of P...
Quantitative top-down proteomics of human colorectal cancer cells and tumors
Project Summary It has been estimated that 145,600 people were diagnosed with colorectal cancer (CRC) and 51,020 deaths were predicted due to this disease in 2019 (https://seer.can...
Inflammatory cascades disrupt Treg function through epigenetic mechanisms
PROJECT SUMMARY/ABSTRACT CD4+FOXP3+lymphocytes are expanded within the intestinal inflammatory lesion of Crohn’s disease (CD); however, ongoing inflammation belies presumed anti-in...
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a s...
The Biological Consequences of Age-related Clonal Hematopoiesis
Clonal hematopoiesis of indeterminate potential (CHIP) defined as acquisition of somatic mutations in hematopoietic cells is a common age-related condition. The prevalence of CHIP...
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity
PROJECT SUMMARY Of the greater than 350 Primary Immunodeficiency Diseases (PID) in humans that have been identified to date, the molecular basis of a significant number (~100) of P...
Transcriptional control of NK cell metabolism
Project Summary Natural killer (NK) cells comprise an important arm of the host innate immune system that detects and eliminates virus-infected cells. Newborns and immune-compromis...
Inflammatory cascades disrupt Treg function through epigenetic mechanisms
PROJECT SUMMARY/ABSTRACT CD4+FOXP3+lymphocytes are expanded within the intestinal inflammatory lesion of Crohn’s disease (CD); however, ongoing inflammation belies presumed anti-in...
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a s...
The Role of CCL5 in Hematopoietic Stem Cell Activation and Skewing
Abstract In many inflammatory conditions such as inflammatory bowel disease (IBD) platelet counts rise, resulting in thrombocytosis, but what initiates this platelet up-regulation...
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa Study)
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa) Study Project Summary The incidence of breast cancer in low and middle-income countries (LMIC) is...
2/2 - Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal an...
The Biological Consequences of Age-related Clonal Hematopoiesis
Clonal hematopoiesis of indeterminate potential (CHIP) defined as acquisition of somatic mutations in hematopoietic cells is a common age-related condition. The prevalence of CHIP...
Quantitative top-down proteomics of human colorectal cancer cells and tumors
Project Summary It has been estimated that 145,600 people were diagnosed with colorectal cancer (CRC) and 51,020 deaths were predicted due to this disease in 2019 (https://seer.can...
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity
PROJECT SUMMARY Of the greater than 350 Primary Immunodeficiency Diseases (PID) in humans that have been identified to date, the molecular basis of a significant number (~100) of P...
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity
PROJECT SUMMARY Of the greater than 350 Primary Immunodeficiency Diseases (PID) in humans that have been identified to date, the molecular basis of a significant number (~100) of P...
2/2 - Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal an...
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa Study)
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa) Study Project Summary The incidence of breast cancer in low and middle-income countries (LMIC) is...
Sensitive and quantitative cytokine detection in bats
Project Summary / Abstract Bats have gained attention in recent years as reservoir or suspected reservoir hosts of many high-impact human pathogenic viruses that cause outbreaks an...