Browse All Grants
99,167 grants found
Showing 95,721 – 95,740 of 99,167 grants
Quantitative top-down proteomics of human colorectal cancer cells and tumors
Project Summary It has been estimated that 145,600 people were diagnosed with colorectal cancer (CRC) and 51,020 deaths were predicted due to this disease in 2019 (https://seer.can...
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a s...
The Biological Consequences of Age-related Clonal Hematopoiesis
Clonal hematopoiesis of indeterminate potential (CHIP) defined as acquisition of somatic mutations in hematopoietic cells is a common age-related condition. The prevalence of CHIP...
The Role of CCL5 in Hematopoietic Stem Cell Activation and Skewing
Abstract In many inflammatory conditions such as inflammatory bowel disease (IBD) platelet counts rise, resulting in thrombocytosis, but what initiates this platelet up-regulation...
Inflammatory cascades disrupt Treg function through epigenetic mechanisms
PROJECT SUMMARY/ABSTRACT CD4+FOXP3+lymphocytes are expanded within the intestinal inflammatory lesion of Crohn?s disease (CD); however, ongoing inflammation belies presumed anti-in...
Structural and Mechanistic Elucidation of NAIP/NLRC4 Inflammasomes in Innate Immunity
Summary of the Funded Grant: The goal of the proposed work is to understand the molecular mechanism of NAIP/NLRC4 inflammasome regulation.The NAIP/NLRC4 inflammasomes are defenders...
A Mechanistic Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
The goal of this project is to identify a drug that could be administered to patients who require mechanical ventilation (MV) in our intensive care units ? a drug which would reduc...
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity
PROJECT SUMMARY Of the greater than 350 Primary Immunodeficiency Diseases (PID) in humans that have been identified to date, the molecular basis of a significant number (~100) of P...
Validation and characterization of antibody responses to Plasmodium falciparum antigens identified by protein array screening
PROJECT SUMMARY Malaria afflicts more than 200 million people yearly, with the malaria parasite Plasmodium falciparum being responsible for the vast majority of the ~405,000 malari...
Th1/Th17 Immune Regulation in Severe Allergic Asthma
Project Summary/Abstract This is the resubmission of a grant entitled ?Th1/Th17 Immune Regulation in Severe Allergic Asthma? (1 RO3 AI163794-01) which focuses on the mechanism of d...
Transcriptional control of NK cell metabolism
Project Summary Natural killer (NK) cells comprise an important arm of the host innate immune system that detects and eliminates virus-infected cells. Newborns and immune-compromis...
JAK-STAT Control of Zika Virus-Induced Fetal Injury
Project Summary The current project, Jak STAT control of Zika virus-induced fetal injury (R01 AI143265), includes the processing of many nonhuman primate (NHP) and human tissue and...
Modeling the interaction of physiological and environmental stressors on common variants to psychiatric traits
PROJECT SUMMARY Psychiatric and neurodegenerative disorders are highly heritable and debilitating brain diseases that together affect nearly fifty million Americans, caused by the...
2/2 - Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal an...
The Biological Consequences of Age-related Clonal Hematopoiesis
Clonal hematopoiesis of indeterminate potential (CHIP) defined as acquisition of somatic mutations in hematopoietic cells is a common age-related condition. The prevalence of CHIP...
Quantitative top-down proteomics of human colorectal cancer cells and tumors
Project Summary It has been estimated that 145,600 people were diagnosed with colorectal cancer (CRC) and 51,020 deaths were predicted due to this disease in 2019 (https://seer.can...
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a s...
Validation and characterization of antibody responses to Plasmodium falciparum antigens identified by protein array screening
PROJECT SUMMARY Malaria afflicts more than 200 million people yearly, with the malaria parasite Plasmodium falciparum being responsible for the vast majority of the ~405,000 malari...
2/2 - Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal an...
Integrated radiomic and liquid biopsy monitoring in SWOG S1802: A phase 3 therapeutic trial for metastatic prostate cancer
Abstract Prostate cancer (PC) afflicts more men in the U.S. than any other malignancy and is the second leading cause of cancer death in this population. Recently, new therapies ha...