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15,626 grants found
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Molecular mechanisms of pain chronification
Chronic neuropathic pain (NP) resulting from peripheral nerve injury can cause prolonged suffering that significantly reduces the quality of life in patients.Current treatments sti...
Cost-benefit analysis of hydrogeologic disturbances in underground projects
The overall aim of this project is to develop a method for cost-benefit analysis (CBA) of measures to reduce hydrogeological risks during the construction phase in infrastructure p...
Design of neoantigen-based vaccines against liver cancer
The covid-19 pandemic has created tremendous damage to the world´s economy and society, but it has also highlighted the importance of science and innovations as tools to survive an...
Characterization and quantification of synaptic populations
Plasticity of synapses is an integral component during development and aging, is further assumed to form the basis of learning and memory and is implicated in a range of diseases....
Characterization of the ribosome generating peptides for major histocompatibility class I (MHC-1) tolerance from pre-spliced mRNAs.
Cancer vaccines, CAR T cells and immune checkpoint inhibitors exemplify how the immune system can be exploited for cancer treatments.A cornerstone in the efficacy of these therapeu...
Reinventing landscape planning for targeting “undisciplined” environmental challenges
Landscape planning has been (re)introduced and reinvented several times in Swedish planning history. This has been done to cope with new, complex and interdisciplinary environmenta...
Herd immunity in food crops: promoting efficient and durable use of biocontrol and chemical fungicides
Herd immunity is a form of indirect protection from disease that occurs when a sufficient percentage of a population becomes immune to infection through e.g. vaccination thereby re...
Mechanisms and evolution of inborn genetic errors affecting enteric virus infections
The genetic make-up of an individual contributes to the susceptibility and response to viral infections.Studies have indicated that as many as one in every 500 Caucasian has select...
Effects of tele-yoga on individuals with heart failure: a randomised controlled trial with a process evaluation and health technology assessment
Persons with heart failure have a poor quality of life. Medical yoga involving movements, breathing exercises, and meditation can improve physical and mental outcomes. However, per...
Local Economic Sustainability and Development in rural areas in Sweden. - A study of policy development in areas with geographical disadvantages.
Rural areas with declining population bases face many sustainability-related challenges.Limited access to capital, high dependency ratios and declining tax bases hamper the transit...
Cellular and molecular mechanisms in the limbic system for the psychiatric manifestation of Huntington disease
The aim of the project is to identify key cellular and molecular mechanisms for psychiatric symptoms in Huntington disease (HD). HD is a fatal neurodegenerative disorder caused by...
Gene Knock Up at the post-transcriptional level to model and treat neurological disease
One of the important unresolved questions in biomedicine is our inability to conditionally modulate endogenous gene expression limited to naturally expressing cells.This inability...
Prevention of Chemotherapy-Induced Peripheral Neuropathy by Modulation of Cellular Membrane Transport and Intracellular Unbound Drug Exposure (PreventCIPN)
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious and common adverse event after cancer treatment. Multiple molecular mechanisms are linked to CIPN-sites in the periph...
The gut-brain axis in Parkinson’s disease - epidemiologic and genetic studies
The purpose of this project is to increase our understanding of the etiology of Parkinson’s disease (PD).The project aims to: 1) investigate whether inflammatory gastrointestinal c...
Determining the mechanisms behind onset and progression of chronic kidney disease
The research projects in this proposal are focused on the mechanisms behind chronic kidney disease (CKD), specifically glomerular disease with mesangial cell involvement. CKD affec...
Transthyretin amyloidosis and therapy: bridging the gap between laboratory and clinical research
This proposal sets out an ambitious programme of research that aims to deepen our understanding of transthyretin (TTR) amyloidosis, and to narrow the gap between biochemical/biophy...
Smell from nature and reduction of human stress in urban environments
The aim is to identify smells from nature that reduce human stress and implement the findings in urban settings.There is a lack of in-situ perceptions of natural smells as stress r...
A Noradrenergic Marker for the Early Detection and Personalized Treatment of Alzheimer’s and Parkinson’s diseases
The aim of this project is to identify the alterations in the major source of noradrenaline in the brain, the locus coeruleus, and establish whether these alterations can detect Al...
Innovative tools in precision medicine to understand and predict immune-mediated and haematological adverse drug reactions
The purpose of Precision Medicine is to treat patients with optimal efficacy and a minimum of side effects. Despite therapeutic advances, side effects cause a great deal of unneces...
Back to the drawing board: reconfiguring of service provision for forced migrant survivors of sexual and gender-based violence, a participatory planning project
Experiences of sexual and gender-based violence (SGBV) are common among forced migrants.Their unprotected legal status, absence of social support, financial difficulties and insecu...