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44,293 grants found
Showing 41,241 – 41,260 of 44,293 grants
Evaluating the health impact and cost-effectiveness of Ways-to-Wellbeing, a whole system approach to mitigate poverty over the life course.
Background: Individuals who face financial difficulties are at risk of poor health, this contributes to the stark inequalities in health between social groups in the UK. Risks of p...
Using multimodal normative modelling to predict clinical outcomes in early psychosis
Individuals at the early stages of psychosis already suffer from neuroanatomical, neurofunctional and neurocognitive alterations.However, it is not clear how these alterations inte...
Understanding the interaction between human milk oligosaccharides and the gut microbiome in preterm infant health and disease
Necrotising enterocolitis (NEC) is a leading cause of death in babies born extremely preterm.NEC infants generally have increased gram-negative bacteria compared to matched control...
The University of Bristol Translational Partnership Award 3
The University of Bristol is committed to facilitating culture change in the academic community’s approach to and capability in translation: the TPA has profoundly contributed to t...
Informing models of Influenza antigenicity using structural biology
Influenza viruses cause hundreds of thousands of deaths each year.Despite a long-standing awareness of 'flu' in the research community, leading to the availability of vac...
Integrating genomic and serological surveillance for geographically targeted control of vampire bat rabies in Central America
Virus genome sequencing is increasingly used in outbreak control.By combining the evolutionary insights gained from sequence analyses with case data and geographic information, cur...
The evaluation of novel GBS conjugates prepared from GBS capsular polysaccharides and GBS conserved surface proteins
The GBS Vaccine Development Project at Biovac is a dual-focussed program with the aims to develop conjugate vaccines for maternal immunization to prevent GBS infections in newborns...
Full Value of Vaccines Assessment for Invasive Non-Typhoidal Salmonella Vaccines
The need for iNTS vaccines is now increasingly being recognized, but there is no iNTS vaccine available for use in humans.Several potential iNTS candidate vaccines are being develo...
Defining differential role(s) of the TAM receptor Axl in atherosclerosis
The TAM receptors are a distinct family of three receptor tyrosine kinases, namely Tyro3, Axl and MerTK, which play critical roles in cancer, inflammatory disorders and cardiovascu...
Exploiting and advancing single-cell proteomics to identify novel pathways to disrupt RNA virus infection.
Single-cell studies have been transformative in biology, dominated by single-cell transcriptomics.Recently, methods for single-cell proteomics by mass spectrometry (SCoPE-MS/SCoPE2...
Non-surgical joint distraction orthosis to treat thumb base osteoarthritis
Patients have prioritised new non-surgical treatments for hand osteoarthritis The joint at the base of the thumb is commonly affected in those living with hand osteoarthritis. Thum...
Proof of Concept - Dalberg
This proposal is to help develop an initial proof of concept of the Transformation Programme pilot for public engagement leaders.We propose working for ~4 weeks to help refine and...
Molecular trade-offs between adaptation to salinity and immunity in three-spined sticklebacks
Climate change and its consequences on the oceans represent major challenges for marine species, which either need to migrate to remain in their optimal niche or need to adapt to a...
The steel industry, circularity and the stock-flow-service nexus
Steel is the world’s most recycled metal, yet only 21% of the global demand is met through scrap, which highlights the gap between the present reality and the ideals embedded in th...
Discrete noise in stochastic active flows
A new mathematical theory for stochastic flows composed of active particles making discrete decisions will open new avenues of research and build towards novel solutions to challen...
Memristor-based neural interface for massively parallel recording and modulation of neural activity
High signal-to-noise, scalable and minimally invasive recording and stimulation of the nervous system of intact animals is of fundamental importance to advance the understanding of...
A chemical biology approach to developing cyclic peptide Protacs
A chemical biology approach to developing cyclic peptide Protacs
Quantum Zealous Fully Probabilistic Framework for Anticipating and Controlling Quantum Systems, (QuaCoq)
QuaCoq will explore new ways of using external signals to actively influence and manipulate the evolving state of quantum systems at the level of atoms, molecules and particles.By...
Tensor and wreath products of symmetric groups
The Kronecker and plethysm coefficients describe the decompositions of products of symmetric functions into their simple constituents. They are as ubiquitous across mathematics as...
Addressing unobserved heterogeneity in road safety analysis
Despite significant improvements over the last decades, road safety remains a major concern in most countries, including the UK.For example, fatality statistics have flatlined duri...