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Discovering new pathways of lymphocyte specification and function
The co-ordinated development and differentiation of lymphocytes is critical to producing the bespoke immune responses required to combat specific pathogens, but also to maintaining...
Neuro-immune-stromal pathways sense environmental change to regulate repair versus remodelling during airway disease
This application will test the hypothesis that pulmonary immune homeostasis is maintained by a network of tissue resident cells that continually monitor environmental change.Disrup...
Hybridisation in urogenital schistosomiasis (HUGS): A multidisciplinary longitudinal population study revealing the transmission biology, epidemiological impact and clinical importance of Schistosoma haematobium-hybrids in Malawi
Our discovery of Schistosoma haematobium hybrids co-infecting Malawian children exposes critical knowledge gaps in WHO’s preventive chemotherapy (PC) strategy for schistosomiasis.O...
Decoding Genetic Studies from Pakistan - A Review of International, Regional and Local Guidelines and Compliance.
I conducted research for my Masters thesis to explore, identify and examine ethical guidelines available for genetic studies and to then analyse and describe the extent to which re...
Preventable axon degeneration in human disease
Programmed axon degeneration (or Wallerian degeneration; WD) is a preventable and druggable mechanism of axon loss. WD is well-characterised in animals and highly conserved. Blocki...
Impact of autophagy on lymphocyte stemness
Efficient T cell responses rely on heterogeneity, characterized by the rise of effector and memory cells. Autophagy, responsible for homeostatic degradation and recycling of cell c...
The role of non-histone proteins in chromosome structure and function during mitosis
I propose to study how a set of key proteins (condensins I/II, cohesin, Kif4A, topo IIα) mold the chromatin fibre into its characteristic rod-shaped helix of loops in mitosis.Using...
A high-quality connectome of the complete female adult Drosophila central nervous system
We previously proposed to generate a complete connectome for the adult male Drosophila central nervous system (CNS), comprising both brain and nerve cord.Capitalising on that inves...
The contribution of spinal inhibitory circuits to aberrant excitability in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease targeting motoneurons, leading to paresis and death.Changes in spinal microcircuits have been suggest...
Evaluation of Footwear Fit Guidelines Under Pressure in At-Risk Feet
Background: Incorrectly fitted shoes are implicated in one in five diabetes related foot ulcers, yet there is a lack of consensus around the clinical definitions of fit.Recommended...
Understanding how BMP9 protects from diabetes-induced blood retinal barrier breakdown
Breakdown of the blood retinal barrier (BRB) drives progression of diabetic retinopathy. BRB disruption leads to fluid extravasation into the retina, which is known as diabetic mac...
Structure, mechanism and dynamics of recoding in viral infection
Many RNA viruses (e.g.SARS-CoV-2, HIV-1) have evolved ways of reprogramming translation to expand the coding capacity of their small genomes. ‘Recoding’ events such as -1 frameshif...
Epilepsy and neurodegeneration : disease mechanisms and early detection
Cognitive decline represents a significant and debilitating co-morbidity for patients with epilepsy which is poorly understood with an urgent clinical need for diagnostic, preventa...
Defining the molecular determinants required for Leishmania life cycle progression and virulence
Leishmania parasites cause a neglected disease on the WHO priority list.During their life cycle, these single-celled parasites must migrate through the sandfly (promastigotes), pre...
Understanding non-coding genomic variation in neurological disorders
The vast majority of DNA is non-coding, repetitive, encompasses a significant proportion of disease risk and is divergent across populations.Major bottlenecks in the past restricte...
Neuroinflammation and its role in precision physiotherapy for patients with entrapment neuropathies
Entrapment neuropathies are the most common conditions causing nerve-related pain. Even though Physiotherapy is the recommended treatment, research suggests only modest benefits. A...
The molecular aetiology of central obesity: moving from variant to function using large-scale data-driven approaches.
Central obesity is a leading contributing cause of illness and death across the world. Currently available strategies for prevention and treatment of this condition are manifestly...
CRISPR/Cas-based biosensors for rapid, precise, and cost-effective point-of-care diagnostics
Biosensors
Concepts Worth Having: A Theory of Reasons for Concept Use
Reasons for Concept Use
Best-in-class low-cost mobile hydrogen refueller for a zero-emission transportation sector
This proposal makes the case that if the EU wishes to accomplish a clean energy transition to achieve its sustainability goals, it will, inter alia, require hydrogen at large scale...