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44,293 grants found
Showing 1,641 – 1,660 of 44,293 grants
Earlier diagnosis in women at high risk of breast and ovarian cancer
Background Recent advances allow tiny amounts of cancer-derived DNA and proteins to be detected in blood.These have been utilised to develop commercial cancer screening tests for t...
Transposable Element Activation in Pre-invasive and Early Invasive Breast Cancer Development in High-Risk Women: Developing a Spatial Proteogenomic and Liquid Biopsy Platform for Molecular Characterization and Early Detection
Background Women carrying germline BRCA1/2 mutations (gBRCAm carriers) have a 75% lifetime risk of developing breast cancer (BC). There is a need for additional biomarkers to predi...
Cancer surgery at systems medicine level: simultaneous molecular mapping and resecting of solid tumours using spectroscopically guided semi-autonomous surgical robots- SU2C
In spite of the tremendous progress in cancer biology and the development of targeted drug therapies still >80% of curative interventions are surgical in case of solid tumors.Wh...
Mapping intestinal metaplasia progression across the upper gastrointestinal tract through a common precancer lens
Intestinal metaplasia is a precancerous condition that occurs in the oesophagus (known as Barrett's oesophagus, BO) and stomach (known as gastric intestinal metaplasia, GIM),...
CRUK Children's Brain Tumour Centre of Excellence 2024
Almost no new treatments of childhood brain tumours have been developed in over 50-years: these diseases continue to kill more children than any other cancer.Therefore, in 2018 we...
CRUK Cambridge Clinical Academic Training Programme / Year 1 QQ2
The Vision of our Clinical Academic Training Programme (CATP) is ‘To be the international Centre of choice for clinicians seeking doctoral training in the cancer sciences’.Our miss...
Associations between androgen deprivation therapies and adverse cardiovascular outcomes in men with prostate cancer: a population-based cohort study in England
Background: >500,000 men are living with or beyond a prostate cancer (PC) diagnosis in the United Kingdom.Cardiovascular disease (CVD) is a leading cause of mortality in PC surv...
Developing evidence and theory-informed digital videos employing a user-centred participatory approach, to support the early detection of skin cancer (EDSC) via self-examination of the skin (SSE), focused on at-risk (older men) and under-served populations (‘people of colour’)
Background More people are getting skin cancer and dying from it; climate change may drive this further. People are likely to live longer with better prognosis if cancer is diagnos...
Exploiting pyrimidine metabolism as a cancer prevention and intervention strategy
Background: In the earliest stages of premalignant progression, changes in the microenvironment play a key role in supporting tumour initiation. These favourable environments prime...
Use of spatial proteomics to dissect an emerging inflammatory pathway for targeted cancer prevention
Background Chronic inflammation is a hallmark of ageing and a major cause of age-related cancer.A key contributor is the milieu of factors secreted by senescent cells known as the...
Molecular Mechanisms of Transgenerational Epigenetic Inheritance
Transgenerational Epigenetic Inheritance (TEI) is the process by which carriers of non-genetic information, such as DNA methylation, histone modifications and non-coding RNAs, are...
Allosteric modulation of class B1 GPCRs via cholesterol binding sites
Class B1 GPCRs are key targets for prevalent diseases, but existing peptide drugs targeting these receptors have limitations that urge the development of novel small molecules, par...
Proposal for a CSIS Alliance Working Group on Climate and Health
The CSIS Bipartisan Alliance for Global Health Security will launch a Working Group on Climate and Health in the second half of 2024 for an initial one-year period, with the expect...
The African Bioinformatics Institute
We propose to establish an African Bioinformatics Institute (ABI) that will create a well-coordinated federated network of computational biologists and data scientists across Afric...
FAST-EM – Fast Accessible Serial Transmission EM
Mapping the connectome of whole brains of multiple individuals or of larger animal species is very valuable to neuroscience. Presently, the only techniques capable of delivering co...
Automated Generation of Galaxy tools
We will create a generalizable set of libraries and best practice guidelines for the programmatic creation of Galaxy tools.We will leverage our experience in creating one-off scrip...
Sensitising brain MRI to cell type and shape
We propose to sensitise brain MRI to cell type numbers, shapes, and connectivity. The goal in each case is to achieve cell specificity.We will do so by (1) developing novel molecul...
An animal-free future for heart research: functional characterisation of novel refined human engineered heart tissue.
This award aims to combine two technologies previously developed with NC3Rs funding to characterise and validate refined human engineered heart tissue (hEHT) in order to help augme...
Calf-Free Research: Developing robust approaches to replace Foetal Calf Serum with synthetic alternatives in cell culture
This project, led by the Francis Crick Institute’s Cell Services Platform, focuses on evaluating the effects of commercially available non–animal-derived serum alternatives on cell...
Investigating the replacement of non-animal derived antibodies and serum in academic research
The MRC LMS seeks £90,000 to evaluate non-animal derived products across several workflows throughout the institute.The LMS, an internationally renowned research institute, is dedi...