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201,169 grants found
Showing 198,441 – 198,460 of 201,169 grants
Investigating Mechanisms of Hyperprogression on Anti-PD-1 Immunotherapy
Abstract The number of cancer patients being treated with checkpoint blockade immunotherapy (CBI) targeting the PD- 1/PD-L1 pathway is increasing dramatically.Recently a novel and...
Genetic analysis of lung cancer susceptibility
Abstract Although tobacco exposure is the major determinant of lung cancer, only about 15% of smokers develop lung cancer.In this study, we seek to identify genetic effects that in...
Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors and lung cancer prognosis
Project Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of antidiabetic drugs. The use of this class of drugs is on the rise.In addition to it...
Improving CAR T cell therapy for brain tumors using immune competent models
PROJECT SUMMARY/ABSTRACT The overall objective of this study is to engineer a potent CAR T cell therapy for high grade glioma (HGG), a subgroup of brain tumors for which outcomes r...
Effect of Gut Microbiome Dysbiosis in the Pathobiology of Multiple Sclerosis
Despite the association between gut microbiota and multiple sclerosis (MS) being increasingly appreciated, the mechanism through which gut bacteria and their metabolites modulate d...
A role and regulation of glucose responsive lipolysis in pancreatic beta cells
T2D is a major health problem for US veterans that imposes significant physical, financial, and emotional tolls. Thus, there is a strong and urgent need for an effective and widely...
Methods for Mendelian randomization and mediation analysis using integrative genetic and genomic data for breast cancer
Project summary Haoyu Zhang, PhD is a statistician whose ultimate career goal is incorporating advanced causal inference techniques into genetics and biological research in order t...
Identifying new drivers of ovarian cancer from the non-coding genome by converging germline risk variants and somatic mutations
PROJECT SUMMARY/ABSTRACT The goal of the proposed research training program is to provide tailored additional training to facilitate successful career development throughout the co...
Investigating the Role of Radiation-induced Cell Death in Innate Lymphoid Cell Activation within Unique Tumor Microenvironments
PROJECT SUMMARY: The role of ionizing radiation as an ?in situ? vaccine is based on radiation?s ability to induce the release of tumor antigens which activate antigen-presenting ce...
Regulation of the neuroinflammatory response in autoimmune uveitis
Research Abstract: Autoimmune uveitis is a serious sight-threatening condition defined by an autoreactive immune response against the retina and uveal tissues.In autoimmune uveitis...
Microvascular mechanisms of growth restriction after environmental toxicant exposure
ABSTRACT The uterine circulation and placenta are specifically designed to regulate the flow of blood and transport of es- sential nutrients to the fetus.Disruption of maternal hem...
Fine-Mapping Genome-Wide Associated Loci using Multi-omics Data to Identify Mechanisms Affecting Serious Mental Illness
Genome-wide association studies have been key for identifying genetic variation associated with psychiatric disorders.Whenever these GWAS are based on large sample sizes, however,...
The role of mitochondria in hematopoietic stem cell self-renewal
Abstract Hematopoietic stem cells (HSC) sustain the production of all blood and immune cells throughout life by differentiating into all blood lineages and regenerate long-lived HS...
Efficacy of Mind-Body Approaches for the Treatment of Chronic Pain with Psychological Comorbidity
Chronic pain (CP), defined as persistent (>6 months), non-malignant, musculoskeletal or generalized pain, is a prevalent and costly public health problem. CP is highly prevalent...
Multiethnic genomic epigenomic and transcriptomic fine-mapping and functional validation analysis of schizophrenia and bipolar disorder risk loci
PROJECT SUMMARY Serious mental illness (SMI) that includes schizophrenia (SCZ) and bipolar disorder (BD) are common, complex and debilitating psychiatric disorders that together af...
Identifying gene regulatory networks controlling photoreceptor specification by transcriptomic and epigenomic analysis of retinal development in cone-dominant retina
Project Summary While degeneration of cone photoreceptors is the ultimate cause of blindness in photoreceptor dystrophies, mouse and human retinas are rod photoreceptor-dominant, a...
ERβ repurposes EZH2 to suppress oncogenic NFκB signaling in TNBC
PROJECT SUMMARY/ABSTRACT Breast cancer remains the most commonly diagnosed cancer in women and is the second leading cause of cancer-related deaths among women.Triple Negative Brea...
Genetic Biomarkers for Risk of CLL Progression among high-count MBLs
Monoclonal B-cell lymphocytosis (MBL) is a precursor state to chronic lymphocytic leukemia (CLL), and one of the most common premalignant conditions.MBL is present in 5-10% of the...
Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders
PROJECT SUMMARY/ABSTRACT Kidney disorders comprising acute kidney injury (AKI), chronic kidney disease (CKD) and end-stage renal disease (ESRD) account for significant morbidity an...
Small Molecule KLF15 Agonists for Kidney Disease
The Centers for Disease Control and Prevention estimates more than 15% of adults in the United States, over 30 million Americans have chronic kidney disease (CKD).Podocytes are epi...