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15,626 grants found
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Defective hantavirus genomes as a determinant of the host immune response and pathogenesis
Hantaviruses are a family of zoonotic viruses naturally found in rodents. In humans some hantaviruses can cause highly pathogenic disease.Hantavirus-induced disease is characterise...
The Gut-Brain Connection: How Appetite Peptides Drive Alcohol Use Disorders
The overall aim is to outline the mechanisms underlying alcohol use disorder (AUD) and thereby enable novel treatments. AUD strongly contribute to morbidity and mortality and have...
Life course psychosocial factors and early signs of Alzheimer´s Disease and Related Dementias
This project aims to answer the following questions: (1) Can early life adversities (ELA) predict later life early signs of Alzheimer´s disease and related dementia (ADRD) (cogniti...
Primary cilia reveal novel biomarkers for autism in preterm infants
Autism is a neurodevelopmental disorder with increased risk in preterm babies. Identifying early biomarkers can help improve early diagnosis. Cilia are cellular structures that are...
Immune checkpoint molecules: signifance in rheumatoid arthritis and iatrogenic inflammatory arthritis
The aim of the project is to study the role of immune checkpoint (ICP) molecules on T cells and their receptors on joint fibroblast-like synoviocytes (FLS) in the pathogenesis and...
Genes(is) of Inspiration - Screen, detect and protect against inflammation induced life-threatening events.
Immature cardiorespiratory control in infants may result in apneas, sudden unexpected postnatal collapse (SUPC), secondary hypoxic brain damage and SIDS. We have shown that prostag...
The gut environment as an instructor of immune tolerance and allergy development
Rationale: The human immune system shows interindividual immune variation that relates to genetic differences as well as environmental exposures.The general purpose of our work is...
Identification of the mechanism underlying TTR amyloidosis
Transthyretin (TTR) amyloidosis is a systemic disorder that can be both inherited and sporadic and untreated it is lethal within 3-10-years.The disease is caused by amyloid formati...
Genetic studies of prostate cancer aggressiveness and prognosis
This project aims to further advance the understanding of inherited genetic determinants for prostate cancer (PCa) aggressiveness and prognosis.To achieve this, we will apply large...
A precision medicine approach to harness the therapeutic potential of lipoxins to reduce inflammation and obesity-related cardiometabolic disease
Purpose & goalsThis study investigates if the pro-resolving “lipoxin” lipids can be used as a therapeutic to reduce obesity-related inflammation and cardiometabolic disease. Li...
Stockholm in heatwave - housing, people and public health
There is substantial evidence linking high outdoor temperatures to an increase in population morbidity, but little is known about the relationship between indoor heat exposure and...
Swedish Mammography Risk Stratified Trial - SMART
The aim of breast cancer screening is early detection of breast cancers. Mammography screening is so far the only proven method that reduces mortality from breast cancer.Mortality...
aCent - A model for person-centered care and support in allogeneic stem cell transplantation
The aim is to develop, implement and evaluate a model, the aCent model, for nurse-led person-centered support interventions, and evaluate the model’s effect on patients’ and family...
Identifikation av nya principer kring type 2 immunitet och eosinofili vid vävnadsinflammation
Aims: This project represents an internationally leading effort for decoding the immune mechanisms regulating eosinophilic inflammation in respiratory diseases (asthma, allergic rh...
Impact of B cell and autoantibody clonal complexity in rheumatic disease
Autoreactive B cell and antibodies are central in the pathogenesis of rheumatic autoimmune diseases.Distinct autoantibody specificities are the hallmarks of rheumatoid arthritis (R...
Psychedelic compounds: Mechanisms, circuits and behavioral outcomes of antidepressant treatment response
Mental health disorders affect 84 million Europeans and are associated with an economic burden of 100 billion SEK/year in Sweden alone.Evidence from clinical trials suggests that a...
Transition capacity to manage extreme weather events by making room for the water - from mind to map (room4water)
Room4water aims to link spatial planning, risk management and climate adaptation with nature conservation through cross-sectoral and cross-boundary cooperation within a case study...
Mitovesicles: a novel approach to understand and tackle neurodegeneration in Alzheimer ́s disease
Recent evidence suggests that mitochondria, which are dynamic and signaling organelles that supply energy in form of ATP, can be transferred between neuronal cells in specialized e...
Molecular PET imaging and plasma biomarkers in Alzheimer´s disease and other neurodegenerative diseases.
This project aims to develop and characterize new brain and fluid biomarkers to increase our understanding of the cause of future cognitive impairment and allow implication of ne...
Finding treatment targets through a new understanding of the link between neural plasticity and cognitive mechanisms in chronic pain
Chronic pain is a major health problem, and many patients suffer from pain in absence of any clear tissue- or nerve damage. Instead, their pain can be caused by abnormal regulation...