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15,626 grants found
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Increasing endogenous degradation of amyloid beta as a treatment strategy for Alzheimer’s disease
Alzheimer’s disease (AD) is caused by increased levels of amyloid beta (aβ) in the brain, leading to the formation of toxic aggregates.Endogenous aβ is degraded by neprilysin, and...
Generating CAR-T cells in vivo by gene targeting
T cells expressing chimeric antigen receptors (CAR) have transformed cell therapies against some cancers.As a postdoctoral fellow, I evolved a synthetic adeno-associated virus (AAV...
Druggable RNA as targets for antimicrobial compounds
The latest coronavirus pandemic and the ongoing antibacterial resistance crisis highlight the need for new treatment options of pathogenic microbes.Here, we will use state-of-the-a...
Oncolytic virus-based immunotherapy for lymphoma: harnesing the power of dendritic cells
Lymphomas are the 5th-10th most common cancers in most countries worldwide.Low-grade B cell lymphomas, the most common lymphoma types, are generally incurable due to relapses and t...
Multidimensional chemical proteomics for transforming tumor vulnerabilities into novel therapeutics in colon cancer
This project aims to combine frontline technologies in mass spectrometry-based proteomics and systems biology to study the cell-cell interactions within the colon tumor and its com...
Delineating the communication between endogenous clocks and their role in multimorbidity
Life on Earth evolved to function in harmony with geophysical phenomena such as the day-night cycles. Hence, many biological processes display endogenously generated 24-hour rhythm...
Curing Sepsis - a personalized bench-to bedside approach for prediction and treatment of short and long-term complication in sepsis
Purpose and aims: Sepsis is considered the nr 1 most preventable cause of death in hospitals. Despite this fact it is as common as cancer and as deadly as myocardial infarction.The...
Towards precision medicine in patients with inflammatory bowel disease; Translational studies of the intestinal microenvironment and host immunity
There is an urgent need to develop biomarkers predicting disease course and therapy outcome in patients with inflammatory bowel disease.Also, clinically accessible tools to guide c...
Uncovering the mechanisms behind rotavirus and norovirus disease symptoms
Rotavirus and norovirus infections causes diarrhea and vomiting but also fever and sickness feeling.While vomiting and sickness symptoms are mediated from the brain, diarrhea is me...
Harnessing the potential of smooth muscle cells for therapy in atherosclerotic vascular disease
Smooth muscle cells (SMCs) are the main structural vessel component.In cardiovascular diseases (CVD) underlined by atherosclerosis, the balance of excessive vs insufficient SMC act...
EPD Berg
Purpose and goal: ** Denna text är maskinöversatt **Our vision is a common tool for the industry, both nationally and internationally, which connects the actual production chain of...
Nitrogen oxides in anesthesia and intensive care
BackgroundNitric oxide (NO) is a pluripotent signaling molecule involved in numerous physiological processes.This tiny gas is classically produced by specific NO synthases, but we...
Ecosystem for an age-friendly village
Purpose and goal:The aim is to make it easier for the elderly to be independent, maintain abilities, reduce the risk of involuntary loneliness, maintain health and enable them to r...
Development of permeability enhancers for oral peptide drug delivery
Macromolecular drug molecules demand advanced drug delivery systems to enable them to be developed as functioning medicines.These drugs, such as peptides, have several advantages...
Sustainable stormwater and cloudburst management in development districts
Purpose and goal:In SODA we work for a change in society towards a more sustainable stormwater and cloudburst management with a focus on development district. It is about adapting...
Beyond chromosomal abnormalities: deciphering the genetic drivers of miscarriage
The ultimate goal of this project is to identify the fetal genetic effects on miscarriage beyond chromosomal abnormalities and understand its phenotypic consequences in pre-implant...
Imagination as a tool for climate action: towards preparedness in the Swedish water sector
The world is currently on a trajectory towards a +3oC warming compared to pre-industrial levels and we are already affected through floods, drought, and water quality deterioration...
Closing the water cycle to increase Urban Resilience to Extreme Events (CUREE)
Temperatures in Sweden are predicted to increase by 3-5oC by 2080, with increases in the frequency of both summer droughts and winter rainfall events predicted.This is a particular...
The economic potential of AgroEcological farming practices in times of severe climatic and economic disruptions
Climate change increasingly threatens agricultural production and global and local food security. At the same time, agriculture is responsible for large greenhouse gasses emissions...
Targeting resistance to first-line cancer therapies
While the efficacy of cancer therapies and the spectrum of available treatments has seen important advances in recent decades, even the newest medicines face an old problem: treatm...