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15,626 grants found
Showing 6,921 – 6,940 of 15,626 grants
Molecular mechanisms for controlling cochlear function
Close to 500 million people are affected by hearing loss severe enough to impair communication.Although hearing aids and cochlear implants are beneficial, they cannot restore norma...
Greenhouse gas (GHG) production in Swedish fiberbanks – combining GHG measurements and microbial analysis for improved assessment (FIB-GHG)
In the aquatic environment, heavily polluted fiberbanks, originating from pulp and paper industry discharges during the 19th and 20th centuries, produce large amounts of greenhouse...
Towards targeted treatment of polycystic ovary syndrome by dissecting its molecular mechanisms and inheritance
Polycystic ovary syndrome (PCOS) is the leading cause of female infertility and linked to type-2 diabetes and endometrial cancer. Progress in managing the disorder is hindered by a...
Combined targeted radionuclide imaging and targeted therapy – a way for precision treatment of prostate cancer
There is a clinical need to improve therapy of disseminated prostate cancer (PCa).My program should provide scientific rationale for the use of theranostics (agents suitable for bo...
Single-cell multi-omics analysis charts the basophil and mast cell differentiation trajectories in normal and aberrant hematopoiesis
Significant efforts have been made to map the differentiation of hematopoietic stem and progenitor cells into the various myelo-erythroid cell types.However, the basophil and mast...
Neutrophil subtypes and periodontal disease; impact of serine proteases
Neutrophils are critical components of inflammation and increasingly recognized as a heterogeneous cell type with multiple distinct subtypes simultaneously present in circulation....
Deciphering determinants of white adipocyte lipid turnover in cardiometabolic disorders
The main function of white adipose tissue (WAT) is to store (lipogenesis) and release (lipolysis) energy.In humans, both pathways are under hormonal control where insulin stimulate...
Molecular phenotyping for precision pharmacotherapy of asthma
Asthma ranks among the most common chronic diseases of industrialized countries.Upwards of 20% of asthmatics present with difficult to control conditions that often respond poorly...
Health systems resilience in managing the COVID-19 pandemic: lessons from regional preparedness plans in Sweden
Research problem and specific questions: Sweden’s emergency preparedness has met several acute challenges in the past years, now in the form of the COVID-19 pandemic. The pandemic...
Targeting NAD metabolism for neuroprotection in age-related ophthalmic and neurodegenerative disease
2.2 billion people live with visual impairment and blindness worldwide.Only ~50% of these cases are directly preventable which highlights the need to further develop and advance tr...
Genetic causes and underlying mechanisms in early-onset osteoporosis
Osteoporosis is characterized by compromised bone strength and fractures. The associated morbidity and mortality have significant human and economic implications. Genetic factors p...
Funktionell proteomik för precisionsmedicin
Cellular activity states are manifested by changes in protein concentration and distribution, but importantly, also by factors such as posttranslational modifications or dynamic in...
MALIGNANT LYMPHOMAS, WITH SPECIAL FOCUS ON MANTLE CELL LYMPHOMA: BIOLOGY, NOVEL TREATMENTS AND SIDE-EFFECTS
Mantle cell lymphoma is the malignant lymphoma with the poorest long-term survival and today the descicions for the best first line treatment is unknown. I am investigating a parad...
Urban environment and early markers of cardiometabolic health in young adults
Cardiovascular and metabolic diseases (CMD) remain the leading cause of morbidity and mortality globally, including myocardial infarction, stroke and type 2 diabetes.Although young...
Environmental impact on pediatric brain development
Childhood cognitive and brain development strongly impacts future academic performance and is correlated to future mental health, including risk for neurodevelopmental disorders.In...
The treatment of insulin resistance to improve stroke recovery in pre-diabetes and type 2 diabetes
AimType 2 diabetic (T2D) and elderly people have severe/persistent post-stroke disabilities and the causal mechanisms are unknown.Insulin resistance (IR), which is a hallmark of T2...
Multifaceted mental health impact of COVID-19 – a cross-country comparison between Sweden and five other European countries
The COVID-19 pandemic has had an unprecedented influence on the global economy and population health.While the scientific community has alerted for adverse mental health impact of...
Kelos as life boats for redlisted species - a potentially hidden source of biodiversity
The species richness of wood decaying fungi in boreal forests are declining and consequently a large number of species are listed as threatened or near threatened on the national r...
Rehabilitation at home – development of a sustainable model, placing person’s needs and environmental resources at heart (InHome)
Each year, 25,000 persons in Sweden have a stroke, and many suffer from disabilities leading to activity and participation restrictions.Despite this, rehabilitation mainly focuses...
Identification of women at increased risk of breast cancer with unfavorable prognosis
In Sweden, four women die from breast cancer every day.The long-term objective of our research is to reduce mortality of breast cancer by improving the early detection of disease a...