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44,293 grants found
Showing 41,361 – 41,380 of 44,293 grants
Understanding and manipulating the dysregulation of interneurons in schizophrenia
Schizophrenia is an incurable disease hallmarked by the presence of positive, negative and cognitive symptoms.Currently, antipsychotic drugs are used to treat some of the positive...
Colour vision in the dark: ecological, physiological and structural basis of rod-rod colour opponency in the frog retina
Most vertebrates, including humans, cannot ‘see colour in the dark’ because the retinal rod photoreceptors that mediate vision in dim light usually come in a single spectral flavou...
INTERSECTIONS
This edition of European Researcher's Night, run independently of all other NIGHTs, will provide a platform from which researchers and publics across Europe can participate to...
EXPLORATHON 2021 - European Researchers' Night in Scotland
Our proposal builds on the success of EXPLORATHON in Scotland from 2014 to date and will deliver a blockbuster editionof the NIGHT across all of Scotland, utilizing both digital ev...
CHILDREN AND GENDER INEQUALITY
Women continue to face large and persistent drops in terms of all labor market outcomes at the arrival of children.Researchers now understand that these “child penalties” on women...
Micro Structure and Macro Outcomes
MICRO2MACRO proposes a research agenda where macroeconomic outcomes emerge as the equilibrium aggregation of decisions by interlinked micro-units of production operating in narrow,...
Impact of interventions to improve recovery of older adults following planned hospital admission on quality of life following discharge: linked evidence synthesis
Background: The number of older adults who are admitted to hospital for planned treatment within the UK is rising. This population have different needs to younger adults which may...
OpticAl Coherence TomograpHy Angiography for the dEtection of Neovascular Age-related Macular Degeneration: a Comprehensive Diagnostic Accuracy Study - the ATHENA study
Background:Age-related Macular Degeneration (AMD) is the most frequent cause of blindness in the UK. Nearly 200 people aged 55-years or above in the UK lose sight daily from the se...
ROTATE Rotation of the fetal head at full cervical dilatation
RESEARCH QUESTIONFor women at full cervical dilatation with persistent malposition of the fetal head requiring a rotational assisted vaginal birth, does manual rotation of the feta...
A Multicentre Study to Investigate a Protocol-Driven Multidisciplinary Service Model to Tackle ‘Spurious Penicillin Allergy’ in Secondary Care (SPACE study)
Research Questions:1. Can a ‘direct’ oral penicillin challenge (DPC) be safely embedded into routine clinical practice within secondary care to de-label ‘low risk’ patients with a...
Early detection of bladder cancer in Yorkshire: Feasibility assessments for implementing a targeted study in populations with high disease specific mortality risk
We will undertake the feasibility steps for a comprehensive early detection programme for bladder cancer across Yorkshire. We will combine home urine dipstick self-testing with com...
Interpretable and probabilistic deep learning models for heart failure risk prediction using temporal and multi-modal UK electronic health records (Mr Yikuan Li)
Recent advances in artificial intelligence (especially deep learning) and the growing access to large-scale datasets such as electronic health records (EHR) from millions of indivi...
Investigating causal relationships between urinary tract infection and acute myocardial infarction or stroke
This project will investigate causal relationships between urinary tract infection (UTI) and acute myocardial infarction (MI) or stroke.Robust epidemiological evidence of a causal...
Targeting multidrug resistance proteins to promote cytoprotective cyclic GMP signalling in heart failure
Cyclic-3’,5’-guanosine monophosphate (cGMP) is a fundamental intracellular signalling molecule underpinning the biological actions of nitric oxide (NO) and natriuretic peptides, an...
The accessible chromatin landscape of cardiac progenitors: characterizing regulatory elements on a genome-wide scale
The harnessing of multipotent cardiac progenitor cells (CPCs) offers massive potential in the development of new therapeutic strategies and approaches for the treatment of cardiova...
Targeting the long non-coding RNA SMILR using small interfering RNA for therapeutic intervention in vein graft failure
Professor Andrew Baker is searching for ways to improve bypass grafting – a very common surgical procedure when surgeons replace blocked blood vessels in the heart.Doctors usually...
The next generation of evidence on cardiovascular disease prevention using device-based assessments of physical behaviour in harmonised pooled cohorts: The Prospective Physical Activity, Sitting and Sleep consortium (ProPASS)
Physical activity, sedentary behaviour and sleep - “physical behaviours” – are risk factors for cardiovascular disease (CVD) risk, although our understanding is limited as the larg...
Unravelling Inflammatory Caspases Co-regulation
The innate immune is the body first line of defence against pathogens.One key pathway of the innate immune system, called the inflammasome, activates signalling proteases named inf...
The cross-national impact of discrimination on health: considering social and genetic vulnerabilities
Aim: This study will use longitudinal data from three cohort studies (n=~78,000) to assess the impact of discrimination based on a range of characteristics on mental and physical h...
The role of the cerebellum in thalamic development
Brain development is susceptible to genetic or environmental perturbations that can disrupt normal maturation and produce life-long deficits.This has primarily been studied in sens...