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44,293 grants found
Showing 1,341 – 1,360 of 44,293 grants
Developing a systematic framework for reconstructing evolutionary histories of viruses with pandemic potential
The accurate estimation of molecular clock rates is crucial for characterising virus evolutionary dynamics and reconstructing their natural history.While modern sequencing software...
Elucidating monocyte-specific disease mechanisms in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that disproportionally affects young women, particularly those from ethnic minority groups.Lupus nephritis (L...
Validating myo-inositol, a novel renal biomarker for kidney disease.
Kidney diseases are a major global health concern. Early diagnosis and timely treatment are important for improving clinical outcomes.However, the existing creatinine-based diagnos...
Evaluating the impacts of climate and environmental stressors on migration and migrant health in Brazil
Climate and environmental change are key drivers of human displacement and migration, which may compromise the physical and mental health of affected populations.The deleterious im...
Removing barriers to advanced imaging and machine learning-based analysis
While imaging and image analysis technologies have undergone dramatic technological leaps in the last decade, progress has been uneven at the global scale(1).Although some groups a...
Enhancing islet and beta-cell transplant engraftment by targeting chemokine-driven inflammation
Immune cell mediated beta-cell destruction results in only 50% of islet transplant recipients remaining insulin independent at 5-years. Therapeutics targeting immune cells are succ...
Exploring miRNA heterogeneity within pancreatic beta-cell subpopulations to improve beta-cell therapies
Pancreatic β-cells within islets are molecularly and functionally heterogeneous.Single-cell RNA sequencing (scRNA-Seq) has revealed distinct β-cell subpopulations with unique trans...
Brain cells for beta cells
The proposed research aims to investigate the potential of choroid plexus epithelial cells (ChPECs) as a novel cell therapy for Type 1 Diabetes (T1D).ChPECs, known for their secret...
A mechanism for persistence and resolution of anxiety after exposure therapy
Exposure therapy is the most effective treatment for anxiety disorders. However, even after successful treatment, with time many experience spontaneous recovery of fear and even fu...
Protection Against Invasive NTS Disease (PAINTS) - correlates of protection towards vaccine licensure
Invasive Non-Typhoid Salmonella (iNTS) disease is a high-burden high-fatality bloodstream infection across Africa, associated with young age and malaria.Two candidate-vaccines (con...
A Holistic View of Gene Expression in Archaea
Archaea represent an understudied yet abundant and important group of prokaryotic organisms.Their gene expression machinery is a streamlined version of pol II, including RNA polyme...
Integrating Actions on Air, Climate, and Health: Building Consensus and Advancing Research on Health Effects of Black Carbon
We will conduct a systematic review of the health effects of black carbon (BC), including the exposure-response relationship between BC exposure and a broad range of health outcome...
Research Project Carbon Costing Tool
The Full Carbon Costing Tool project aims to develop a new piece of software to enable researchers to quickly assess the carbon impact of a project in development. An initial versi...
Extending Trials of fractional doses of yellow fever vaccine for policy impact
Yellow fever (YF) is a zoonotic mosquito-borne viral disease endemic in Africa and South America.Over 100,000 YF cases are estimated to occur annually in Africa which, with a case...
IA2030 SP7 Scoping project for Vaccine and Immunization Implementation Research Strategy and Prioritization
This proposal responds to the recognized need for a more responsive implementation research ecosystem for immunization programme decision-makers, in keeping with the objectives of...
Feasibility analysis of nucleic acid-encoded mAb therapies
The rise of nucleic acid-based vaccines prompted interest in their use as alternative vehicles for therapeutic protein delivery.Monoclonal antibodies (mAbs) have been the leading c...
Developing the first innovative treatments against visceral leishmaniasis
Visceral leishmaniasis (VL) affects some of the poorest people on Earth.Prone to outbreaks and fuelled by environmental and climate changes, WHO estimates 50,000 to 90,000 cases pe...
CRUK Lung Cancer Centre of Excellence 2024
In 2014 there were few high-quality funding applications for lung cancer research with stagnation in progress contributing to poor outcomes.The CRUK Lung Cancer Centre of Excellenc...
INFORM - non-invasive early detection of brain cancer using tear fluid proteome profiling (supported by Stand Up To Cancer)
Background: Despite being considered a rare disease, brain cancer represents a significant socio-economic burden, with high mortality rates and disabling effects on patients.Since...
CRUK City of London Radiation Research Centre of Excellence 2024
Over the last five years, CRUK RadNet City of London (CoL) has transformed the radiation research landscape in London, bringing together researchers and clinicians with shared inte...