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44,293 grants found
Showing 1,421 – 1,440 of 44,293 grants
STRESSORS: Monitoring and Assessment of Urban Nature-based Solutions
Urban green infrastructure (UGI) and Nature-based Solutions (NbS) are sustainable solutions to managing urban flood risk whilst offering additional co-benefits (i.e. pollution cont...
Examining the mechanism of chromatin replication and assembly at telomeres
Each human telomere is composed of 10-15 kb of repetitive DNA bound by a protein complex called shelterin, which forms a protective nucleoprotein cap at the chromosome end. In addi...
Investigation of the cancer cell membrane proteome to find new vulnerabilities in non- small cell lung cancer
The surface proteome of non-small cell lung cancer (NSCLC) cells expresses specific pairs of proteins, which can be used as targets for delivering cytotoxic agents (e.g. antibody d...
Determining the role of Cyclin B2 in Genomic Stability
Mitosis is controlled by the major mitotic kinase CDK1 and its regulatory partner, Cyclin B. There are two B-type cyclins in vertebrate cells: Cyclins B1 and B2. Cyclin B1 is essen...
Developing partial system models to assess system-level resilience to perturbations: determining the resilience of pollinator networks
Developing partial system models to assess system-level resilience to perturbations: determining the resilience of pollinator networks to climate change
Beyond 'support': Exploring the use of participatory action research to propose strategies to reduce inequalities in the outcomes and experiences of S
This proposed research has an overall objective to explore how Participatory Action Research (PAR) could contribute to understanding and meeting the needs of Students on Low Income...
Mapping healthy ageing in whole Drosophila with the Mesolens
An ageing global demographic with increased multimorbidity is arguably the greatest challenge facing 21st-century health care systems. Understanding the biological underpinnings of...
Disrupting Flood Risk Management Narratives: Youth-Centred Research into Education, Action and Resilience in Flood Affected Places
Across the UK, as the effects of anthropogenic climate change become more apparent, flood risk is increasing, with 1 in 6 properties now considered vulnerable, up from 1 in 8 (EA,...
Teaching old mice a new trick: the role of new myelin in learning in the aged brain
In the central nervous system (CNS), myelin is primarily produced by oligodendrocytes (OLs) that ensheath axons with myelin segments. Oligodendrocyte precursor cells (OPCs) can dif...
Improving Transcranial Ultrasound Stimulation (TUS) for deep brain stimulation
Effective and focal non-invasive deep brain stimulation using TUS is possible through accurate modelling of the head and focusing of the ultrasound through the skull to target spec...
The last star formation wave that swept the galaxy
We will study ages and compositions of hundreds of thousands of stars in the Galactic disk to determine the timing, strength, spatial coverage, and causes of the last star formatio...
UNDERSTANDING THE PROTEASOME AND ITS EVOLUTION
Proteasomes are essential cell regulators in all eukaryotes.They are large proteolytic complexes that break down and recycle proteins that are old, damaged, or no longer needed, th...
Alteration of core regulatory circuitry factor as major driver of neuroblastoma chemo-resistance
Neuroblastoma is a pediatric cancer that is frequently metastatic and resistant to conventional treatment.Using dose-escalating treatment of temozolomide, our lab has generated a c...
Investigating the biomechanical phenotype of bladder cancer using elastography and its association with the immune landscape and radiation response.
Cancer-associated fibroblast (CAF) mediated increased deposition and cross-linking of collagen increases tumour stiffness and may help cancer evade the immune system response to ra...
Organic molecular heterostructures for quantum technologies
Single organic molecules, when cooled to low temperature, can make excellent photon emitters.The emitting molecules are often included in organic crystals to protect them from envi...
Optimizing microalgae yield and high value molecule production in dim green light
Basic Bioscience Underpinning Heath
Deciphering the immunopeptidome in SWI/SNF driven cancers
The display of human leukocyte antigen (HLA) bound T-cell antigens is central to anti-tumour immunity and has important therapeutic consequences.SWI/SNF deficient cancers have been...
Immuno engineering biomaterials for stem-cell-derived beta cell transplantation in type 1 diabetes
In their PhD project they aim to engineer a biomaterial, which can deliver stem-cell-derived beta cells encased in biomimetic materials which are further functionalised with IL-35...
Unlocking the potential of intersectionality for reducing adolescent mental health inequalities: a mixed methods and theoretically grounded approach
This fellowship investigates issues critical for equitable improvement of young people’s mental health. Health inequalities in the UK are stark and increasing. They are among the g...
Completing the protein-protein interaction picture in situ: new fluorescent tools to monitor homo-oligomerisation
Protein-protein interactions (PPIs) commonly occur in biology with ~650,000 contributing to processes critical to human life. From cancer to dementia, their dysregulation contribut...