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44,293 grants found
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BetaCell Birmingham
Diabetes mellitus is a chronic condition that occurs when the pancreatic beta-cells are destroyed (Type I) or unable to secrete sufficient insulin (Type II) to effectively regulate...
Establishing a Human Lymphoid Organoid and Explant Hub to Replace Animal Models in Immunology Research
Mice have long been the preferred model for studying multisystemic immunity.However, accumulated evidence shows that mouse immunology poorly replicates the genetic, biochemical, an...
Upscaling human stem cell assays to detect autoantibodies in central nervous system disease
There is growing evidence for the role of autoantibodies in common and debilitating disorders affecting the brain, such as psychosis and dementia. Autoantibodies, fortunately, can...
Towards a clinical-trial-in-a-dish: Validating an animal product-free stem cell-derived 3D model of Alzheimer’s disease for drug discovery
Worldwide over 50 million people are living with Alzheimer's disease (AD). Currently there is no effective treatment for AD and most clinical trials have so far failed.This is...
Revolutionizing Micro-Surgical Training By Reducing And Replacing Animal Dependency through Synthetic Biomimetic 3D printed Blood Vessels
This interdisciplinary project focuses on developing alternative animal models for advanced microsurgical training in collaboration with The Griffin Institute (TGI), which boasts a...
Clonal and functional T cell determinants of protection and pathogenesis in tuberculosis.
Tuberculosis (TB), resulting from infection with Mycobacterium tuberculosis (Mtb), kills 1.5 million people per year.The immune system prevents disease in most people who become in...
Supporting adults with cerebral palsy to age well - development of a specialised link worker role
The overarching aim of this project is to develop and assess a specialised cerebral palsy (CP) link worker role to support adults ageing with CP.CP is the most common lifelong phys...
The African Regulatory Leadership Programme
In response to the COVID-19 pandemic, the political leadership of the African Union undertook to invest in local manufacturing capacity for vaccines, therapeutics and diagnostics,...
An AI-driven Automated Platform for High-Throughput 5D Fluorescence Imaging and Data Analysis Applied to Cell Signalling and Drug Discovery
Fluorescence microscopy has emerged as one of the most powerful approaches to investigate the fundamental mechanisms of life, including the complex dynamic events allowing our cell...
OpenSAFELY Phase Two
OpenSAFELY has unlocked access to an unprecedented scale of health data: the GP records of everyone in England - 59m patients - linked onto other key research and health datasets.W...
Dynamic 3D super-resolution ultrasound imaging of micro-circulation and genetically encoded acoustic reporters in vivo
Our vision is to generate a powerful yet highly accessible in vivo imaging platform, enabling non-invasive whole-body microscopy of tissue microcirculation and cellular and molecul...
Organ-Cell-Molecular Imaging (OCMI): Integrating Human Heart Bioimaging Across Scales Using Foundation Models
HOW TO MAP A WHOLE HUMAN ORGAN AT MOLECULAR RESOLUTION ?We will develop a multi-modal bioimaging platform to enable Organ to Cell to Molecular Imaging (OCMI), using machine learnin...
Access to Medicine Foundation
The Access to Medicine Foundation (ATMF) is an independent non-profit organisation that seeks to transform the healthcare ecosystem by motivating and mobilising companies to expand...
Engineering functional tissues by spatiotemporal patterning: 3D bioprinting and optogenetics for directing the organization of cell spheroid building blocks (OPTO-BIOPRINTING)
Each day, 17 people die waiting for organ transplants. Artificial organs or synthetic implants, if available, cannot sustain long-term use.Tissue engineering holds promise for prov...
Enhancing convergence in negotiation positions related to climate and health in the context of the Global Goal on Adaptation in the lead-up to COP29
The proposal will engage with key agenda items and workstreams on climate change and health for 2024-2025, include the UAE-Belém work programme, the role of means of implementation...
Pandemic Risk Assessment and its Intersection with Climate Change: Needs, Opportunities, and Design Considerations
The UN Foundation, in collaboration with the Global Preparedness Monitoring Board (GPMB), the Oswaldo Cruz Foundation, and the US National Academy of Medicine, will hold a 2-day in...
Correlate of Protection against Paratyphoid (CoP-PT)
There is a huge global burden of enteric fever which disrupts the lives of children in settings with inadequate quality water and poor sanitation and it kills.Through our series of...
Sustaining Political Ambition for Action on AMR
This proposal builds upon antimicrobial resistance (AMR) advocacy efforts that the UN Foundation has undertaken in partnership with the Wellcome Trust over the last 10 months.Enabl...
Rift Valley Waters: Indigenous-Led Research on Climate Change and Health in Lake Turkana and Lake Bogoria
Climate change is impacting water resources and ecosystems globally, with severe consequences for Indigenous communities with deep cultural ties to their lands.We propose a Communi...
Neural circuits and computations of flexible navigation
Identifying and navigating to spatial locations important for survival, such as food sources, is crucial for animals. Previous work has described in detail how the mammalian brain...